比特派钱包最新版|krt
验光单上面KRT.DATA下面的数据代表什么? - 知乎
验光单上面KRT.DATA下面的数据代表什么? - 知乎首页知乎知学堂发现等你来答切换模式登录/注册数据数据分析工具验光验光单上面KRT.DATA下面的数据代表什么?这里面D、MM、A、MM1、MM2、A1分别代表什么意思呢?对配眼镜是否有影响呢?如图 [图片]显示全部 关注者10被浏览111,932关注问题写回答邀请回答好问题 11 条评论分享5 个回答默认排序视光师黄素依视光行业里默默耕耘着 关注这是电脑验光单数据(客观验光数据)用于初步了解眼睛度数情况。主要说一下框框内的数据:R代表右眼,L代表左眼;D那一栏是指角膜的屈光度,正常范围一般为43.05D;MM那一栏是指角膜前表面的曲率半径,验配隐形眼镜选择基弧时就是参考这个值来计算的;A那一栏代表的是角膜屈光度所在的方向;R1是水平向;R2是垂直向;AVE是水平与垂直的平均值;拿右眼来说:水平:角膜屈光度42.50D@166,垂直:角膜屈光度43.75D@76,从这两数据可以看出角膜散光有1.25D,轴在166;这个值可以与综合验光仪验出来的散光做比对,看你的散光是角膜散光还是眼内散光;另外,通过角膜屈光度这个值可以评估你的近视是轴性近视还是曲率性近视。从这单子上的数据看,你的近视是轴性近视,而且已经是高度近视,提示要关注眼底情况了,至少要拍个眼底照片、测个眼轴长度。大多数人只关注电脑验光单上的近视、散光这些数据,其实这张单的其他数据不管对于验光师还是被检者来说都挺有用的。有用的话,记得关注我哦,带你了解更多编辑于 2021-05-04 18:17赞同 372 条评论分享收藏喜欢收起武汉配镜点亮哥武汉市洪山区亮哥点亮眼镜工作室 经营者 关注电脑验光数据,一般作为客观(他觉)验光的参考,实际配镜需与主观验光相结合,所谓主观验光就是以“你问我答”的形式通过辨认视力表以及相关测试进行有效、相互沟通,最终确定更为合适的配镜数据。此单除了参考的验光数据外还包括左右眼的一个曲率、曲率半径(比如部分需要配定制的隐形眼镜的参考)。编辑于 2021-05-03 15:55赞同 1添加评论分享收藏喜欢
急性肾损伤的血液透析和滤过 | 《新英格兰医学杂志》综述
急性肾损伤的血液透析和滤过 | 《新英格兰医学杂志》综述
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找到一个基因家族,基本上可以坐等发SCI - 知乎
找到一个基因家族,基本上可以坐等发SCI - 知乎首发于SCI狂人团队切换模式写文章登录/注册找到一个基因家族,基本上可以坐等发SCISCI狂人团队今天分享一篇基因家族的纯生信文章,可以说找到一个没有人做过数据挖掘的基因家族,基本上就是坐等发SCI。今天介绍这篇参考文章发表在Scientific Reports 上,江湖人称“四大神刊”之一,影响因子:3.988,从15年的5.228跌到现在的3.988,经典的OA期刊。参考范文来源:PMID: 33441834 DOI: 10.1038/s41598-020-80336-8。研究背景:角蛋白(KRTs)是上皮细胞的中间细丝形成蛋白,被广泛用作癌症的诊断生物标志物,并与多种癌症的肿瘤发生和转移有关。然而,KRTs在黑色素瘤中的多种表达模式和预后价值尚未阐明。研究方法:在本研究中,我们利用来自GEO,TCGA,ONCOMINE,GEPIA,cBioPortal,TIMER和TISIDB数据库的黑色素瘤患者KRT的转录数据和临床数据进行分析。研究结果:我们发现,KRT1 / 2/5/6/8/10/14/15/16/17的mRNA水平在原发性黑色素瘤和转移性黑色素瘤之间表达差异显着。KRT1 / 2/5/6/10/14/15/16/17的表达水平与肿瘤的晚期分期有关。生存分析表明,KRT1 / 5/6/14/15/16/17的高转录水平与黑色素瘤患者的总生存率低有关。GSEA分析表明,最参与的标志性通路是P53通路,KRAS信号传导,早期雌激素反应和晚期雌激素反应。此外,我们发现KRTs的表达与免疫细胞的浸润之间存在一些相关性。研究结论:我们的研究可能为黑色素瘤预后生物标志物的选择提供新颖的见解。今天分享一篇基因家族的纯生信文章,可以说找到一个没有人做过数据挖掘的基因家族,基本上就是坐等发SCI。今天介绍这篇参考文章发表在Scientific Reports 上,江湖人称“四大神刊”之一,影响因子:3.988,从15年的5.228跌到现在的3.988,经典的OA期刊。参考范文来源:PMID: 33441834 DOI: 10.1038/s41598-020-80336-8。分析思路:1、利用GEPIA在线数据库分析KRTs家族成员在SKCM中的基因表达水平2、利用Oncomine在线数据库进行KRTs家族成员在pan-cancer基因表达情况分析和生存分析3、分析KRTs家族成员在SKCM中基因表达水平与临床病理参数的相关性4、利用SKCM临床数据对KRTs家族成员进行生存分析,寻找有预后价值的成员5、分析KRTs家族成员在SKCM中的蛋白表达水平6、对KRTs家族成员进行功能分析(GO、通路、PPI、免疫相关性)总结:简单的地方:这篇文章利用ONCOMINE,GEPIA,cBioPortal,TIMER和TISIDB等在线数据库进行操作分析,既简单又快捷方便(零代码操作)。比较难的地方:如何发现这样一个没有人做过数据挖掘的基因家族。补充内容:1、没有经费的玩法:利用TCGA数据将这些有预后价值的家族成员构建模型,计算risk score,并且将risk score结合临床因素进行分析。2、有经费的玩法:补充自己的测序数据和功能实验,探索这些家族成员的作用机制。发布于 2021-01-17 10:10SCI 论文数据挖掘生物信息学赞同 223 条评论分享喜欢收藏申请转载文章被以下专栏收录SCI狂人团队手把手教你
角蛋白 10(KRT10)基因 | MCE
角蛋白 10(KRT10)基因 | MCE
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Gene
KRT10 - keratin 10 Gene
KRT10 - keratin 10 Gene
基因
蛋白
疾病
相关产品
直系同源
中文名称:角蛋白 10
种属: Homo sapiens
同用名: BIE; EHK; IHL; K10; KPP; BCIE; CK10
基因 ID: 3858
|
基因类型: protein coding
关于 KRT10
Cytogenetic location: 17q21.2
Genomic coordinates (GRCh38): 17:40,818,117-40,822,614 (from NCBI)
This gene has 2 transcripts (splice variants), 104 orthologues, 68 paralogues and is associated with 9 phenotypes. Restricted expression toward skin (RPKM 7171.9).
功能概要
该基因编码 I 型 (酸性) 细胞角蛋白家族的成员,属于中间丝 (IF) 蛋白超家族。角蛋白是形成中间丝的杂聚结构蛋白。这些细丝与肌动蛋白微丝和微管一起构成了上皮细胞的细胞骨架。该基因的突变与表皮松解性角化过度有关。该基因位于染色体 17q21 上的角蛋白家族成员簇内。[RefSeq 提供,2008 年 7 月]
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the Cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
KRT10 基因产物(2)
mRNA
Protein
Name
NM_000421.5
NP_000412.4
keratin, type I cytoskeletal 10 isoform 1
NM_001379366.1
NP_001366295.1
keratin, type I cytoskeletal 10 isoform 2
KRT10 蛋白结构
Filament
Filament: Intermediate filament protein (145 - 458)
0
100
200
300
400
500
584 a.a.
蛋白主名
其他名称
keratin, type I cytoskeletal 10
CK-10
关联疾病
疾病名称
别名
Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis
AEI
Annular Epidermolytic Ichthyosis
Epidermolytic Ichthyosis, Annular
Ciehk
Ichthyosis Annular Epidermolytic
Annular Ichthyosis Variant Of Bcie
Cyclic Ichthyosis With Epidermolytic Hyperkeratosis
Ichthyosis With Confetti
Congenital Reticular Ichthyosiform Erythroderma
IWC
CRIE
Erythroderma, Ichthyosiform, Congenital Reticular
Ichthyosis Variegata
Erythrokeratoderma, Reticular
Ichthyosis Variegata Micropinnae, Alopecia Universalis, Congenital Ichthyosis, And Ectropion
Mauie
Mauie Syndrome
Aarau Disease
Reticular Erythrokeratoderma
Epidermolytic Hyperkeratosis
Bullous Congenital Ichthyosiform Erythroderma
Bullous Ichthyosiform Erythroderma
EHK
Bullous Erythroderma Ichthyosiformis Congenita Of Brocq
Bcie
Bie
Epidermolytic Ichthyosis
Ichthyosis Bullosa Of Siemens
Superficial Epidermolytic Ichthyosis
Hyperkeratosis, Epidermolytic
Congenital Bullous Ichthyosiform Erythroderma
Bullous Type Ichthyosis
Epidermolytic Palmoplantar Hyperkeratosis
Bullous Ichthyosiform Erythroderma Congenita
Bullous Erythroderma Ichthyosiforme
Sei
Epidermolytic Hyperkeratosis Late-Onset
Epidermolytic Hyperkeratosis, Late-Onset
Autosomal Recessive Epidermolytic Ichthyosis
Arei
Autosomal Dominant Epidermolytic Ichthyosis
Bcie
Bullous Congenital Ichthyosiform Erythroderma
Bullous Congenital Ichthyosiform Erythroderma Of Brock
Bullous Ichthyosis
Ehk
Ei
Epidermolytic Hyperkeratosis
Ichthyosis Hystrix Brocq Type
Epidermolytic Acanthoma
Keratosis
Actinic Keratosis
Hyperkeratosis
Steatocystoma Multiplex
Sebocystomatosis
Multiple Sebaceous Cysts
Multiplex Steatocystoma
Sebaceous Cysts, Multiple
SM
Acanthoma
Ichthyosis
Ichthyoses
Non-Syndromic Ichthyosis
Congenital Ichthyosis
Epidermolysis Bullosa Simplex
Ebs
Epidermolysis Bullosa Intraepidermic
Epidermolytic Epidermolysis Bullosa
Keratoacanthoma
Ka - [Keratoacanthoma]
Well-Differentiated Squamous Cell Carcinoma
Bowen'S Disease
Bowens Disease
Papilloma
Papillomatosis
Mucinous Tubular And Spindle Renal Cell Carcinoma
Mucinous Tubular And Spindle Cell Renal Carcinoma
Lichen Planus
Lichen Ruber Planus
Lichen, Ruber Planus
Ruber Planus
Lp - [Lichen Planus]
Lichen Planus Of Wilson
Wilson Lichen Ruber
Large Cell Acanthoma
Ichthyosis Bullosa Of Siemens
IBS
Ichthyosis, Bullous Type
Bullous Type Of Ichthyosis
Ichthyosis Bullous Type
Skin Disease
Skin Diseases
Genodermatosis
Abnormality Of The Skin
Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease
Dermatologic Disorders
Cholesteatoma Of Middle Ear
Cholesteatoma
Epidermosis Of Ear
Epidermosis Of Middle Ear
Middle Ear Cholesteatoma
Cholesteatoma Of Middle Ear And Mastoid
Cholesteatoma Of Middle Ear And/Or Mastoid
Cholesteatoma Of The Middle Ear
Congenital Cholesteatoma
Primary Acquired Cholesteatoma
Secondary Acquired Cholesteatoma
Cholesteatoma Middle Ear
Cholesteatoma, Middle Ear
Cholesterolosis Of Middle Ear
Cholesterosis Of Ear
Cholesterosis Of Middle Ear
Cholesteatoma Nos
Epidermoid Cholesteatoma
Middle Ear Granuloma
Palmoplantar Keratosis
Palmoplantar Keratoderma
Keratosis Palmaris Et Plantaris
Palmo-Plantar Keratodermas
Keratoderma, Palmoplantar
Keratoderma Palmoplantar
Keratoderma, Palmoplantar, Diffuse
Hyperkeratosis Of Palms And Soles
Palmoplantar Hyperkeratosis
Clear Cell Acanthoma
Acanthoma
Pale Acanthoma
Acanthoma, Clear Cell
Epidermolysis Bullosa
Acantholysis Bullosa
Eb
Borst-Jadassohn Intraepidermal Carcinoma
Intraepidermal Epithelioma Of Jadassohn
Bowen'S Disease, Clonal
Psoriasis
Hidradenitis Suppurativa
Acne Inversa
Suppurative Hidradenitis
Acne Inversa, Familial
Apocrinitis
Hidradenitides, Suppurative
Hidradenitis, Suppurative
Suppurative Hidradenitides
Inverse Acne
Endocarditis
Keratosis, Seborrheic
Seborrheic Keratosis
Keratosis, Seborrheic, Somatic
Basal Cell Papilloma
Keratosis Seborrheica
KERSEB
Nevus, Epidermal
Epidermal Nevus
Woolly Hair Nevus
Epidermal Naevus
Epidermal Nevus Syndrome
Nevus, Keratinocytic, Nonepidermolytic
Epidermal Nevus, Somatic
Nevus, Epidermal, Somatic
Nevus Sebaceous Or Woolly Hair Nevus, Somatic
Nonepidermolytic Keratinocytic Nevus
Epidermal Hamartoma Syndrome
Wooly Hair Nevus
Keratinocytic Non-Epidermolytic Nevus
KNEN
Pigmented Moles
Organoid Nevus Phakomatosis
Nevus Sebaceous
Melanocytic Nevus
Melanocytic Nevus Of Skin
Palmoplantar Keratoderma, Epidermolytic
Epidermolytic Palmoplantar Keratoderma
EPPK
Keratosis Palmaris Et Plantaris Familiaris
Tylosis
Keratosis Of Greither
Diffuse Nonepidermolytic Palmoplantar Keratoderma
Keratoderma, Palmoplantar, Epidermolytic
Unna-Thost Palmoplantar Keratoderma
Epidermolytic Palmoplantar Keratoderma Of Voerner
Ppke
Keratoderma, Epidermolytic Palmoplantar
Palmoplantar Keratoderma, Vorner Type
Hyperkeratosis, Localized Epidermolytic
Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type
Epidermolytic Palmoplantar Keratoderma Of Vörner
Hyperkeratosis Palmoplantar Localized Epidermolytic
Diffuse Neppk
Ppk Diffusa Circumscripta
Thost-Unna Disease
Thost-Unna Palmoplantar Keratoderma
Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type
Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type
Epidermolytic Palmoplantar Keratoderma Of Vorner
Ehppk
Epidermolytic Unna-Thost Disease
Localized Epidermolytic Hyperkeratosis
Palmoplantar Keratoderma Vorner Type
Unilateral Palmoplantar Verrucous Nevus
UPVN
Keratoderma, Palmoplantar, Diffuse
Hyperkeratosis
Palmoplantar Keratoderma, Nonepidermolytic
Epidermolytic Palmoplantar Keratoderma Vorner Type
Type B Tylosis
Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas
Type A Tylosis
Nodular Hidradenoma
Eccrine Nodular Hidradenoma
Eccrine Acrospiroma
Pulmonary Artery Leiomyosarcoma
Leiomyosarcoma Of The Pulmonary Artery
Pachyonychia Congenita 1
Pachyonychia Congenita
Jadassohn-Lewandowsky Syndrome
Pachyonychia Congenita Syndrome
PC1
Pachyonychia Congenita, Jadassohn-Lewandowsky Type
Congenital Pachyonychia
Pachyonychia Congenita, Type 1
Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly
Jadassohn-Lewandowsky Syndrome, Formerly
Jackson-Lawler Type Pachyonychia Congenita
Pachyonychia Congenita Type 1
Jackson-Lawler Syndrome
Jadassohn-Lewandowski Syndrome
Pc
Pachyonychia Congenita Jackson-Lawler Type
Pachyonychia Congenita Jadassohn-Lewandowsky Type
Pachyonychia Congenita Jackson Lawler Type
Pc-1
Pachyonychia Congenita, Jadassohn Lewandowsky Type
Pachyonychia Congenita, Type 2
Eccrine Papillary Adenoma
Papillary Eccrine Adenoma
Eccrine Papillary Adenoma Of Skin
Trichothiodystrophy 1, Photosensitive
TTD1
Tay Syndrome
Trichothiodystrophy With Congenital Ichthyosis
Photosensitive Trichothiodystrophy
Ibids Syndrome
Ttdp
Ichthyosiform Erythroderma With Hair Abnormality And Mental And Growth Retardation
Ichthyosis, Congenital, With Trichothiodystrophy
Pibids Syndrome
Photosensitive Trichothiodystrophy 1
Trichothiodystrophy, Photosensitive
Sulfur-Deficient Brittle Hair Syndrome
Ttd-P
Ichthyosis With Brittle Hair, Intellectual Impairment, Decreased Fertility And Short Stature
Trichothiodystrophy Photosensitive
Trichothiodystrophy, Type 1
Tricho-Thiodystrophy Disorder
Trichothiodystrophy Syndromes
Amish Brittle Hair Brain Syndrome
Skin Papilloma
Cutaneous Papilloma
Papilloma Of Skin
Papilloma Skin
Vohwinkel Syndrome
Mutilating Keratoderma
Keratoderma Hereditarium Mutilans
Khm
VOWNKL
Deafness, Congenital, With Keratopachydermia And Constrictions Of Fingers And Toes
Mutilating Keratoderma Of Vohwinkel
Mutilating Keratoderma Plus Deafness
Ppk Mutilans And Deafness
Congenital Deafness With Keratopachydermia And Constrictions Of Fingers And Toes
Congenital Deafness With Keratopachydermia And Constrictions Fo Fingers And Toes
Palmoplantar Keratoderma Mutilans
Palmoplantar Keratoderma Mutilans Vohwinkel
Ppk Mutilans Vohwinkel
Mutilating Keratoderma Plus Hearing Loss
Ppk Mutilans And Hearing Loss
Eccrine Sweat Gland Neoplasm
Eccrine Skin Neoplasm
Eccrine Tumor
Eccrine Neoplasm
Malignant Eccrine Neoplasm
Ectodermal Dysplasia 9, Hair/Nail Type
ECTD9
Ectodermal Dysplasia 9
Dysplasia, Ectodermal, Type 9, Hair/Nail
Malignant Biphasic Mesothelioma
Mesothelioma, Biphasic, Malignant
Mixed Mesothelioma
Clear Cell Hidradenoma
Clear Cell Myoepithelioma
Eccrine Acrospiroma
Ichthyosis Vulgaris
Ichthyosis Simplex
Dominant Congenital Ichthyosiform Erythroderma
Common Ichthyosis
Fish Scale Disease
VI
Ichthyoses
Congenital Ichthyosis
Toxicodendron Dermatitis
Dermatitis, Toxicodendron
Contact Dermatitis Due To Genus Toxicodendron
Rhus Dermatitis
Dermatitis Toxicodendron
Eccrine Acrospiroma
Acrospiroma
Poroma
Eccrine Hidradenoma
Eccrine Hidradenoma Of Skin
Hidradenoma
Adenoma, Sweat Gland
Benign Neoplasm Of Sweat Gland
Eccrine Poroma
Actinic Keratosis
Solar Keratosis
Actinic Keratosis
Senile Hyperkeratosis
Sk - Solar Keratosis
Keratosis, Actinic
Seborrheic Keratosis
Ak - [Actinic Keratosis]
Sk - [Solar Keratosis]
Erythrokeratodermia Variabilis Et Progressiva 1
Erythrokeratodermia Variabilis
Erythrokeratodermia Variabilis Et Progressiva
Greither Disease
Ekv
Ekvp
PSEK
Erythrokeratodermia Variabilis With Erythema Gyratum Repens
Keratosis Palmoplantaris Transgrediens Et Progrediens
Transgrediens Et Progrediens Palmoplantar Keratoderma
EKVP1
Erythrokeratodermia, Progressive Symmetric
Erythrokeratodermia Figurata, Congenital Familial, In Plaques
Keratoderma Palmoplantaris Transgrediens
Keratosis Extremitatum Hereditaria Progrediens
Erythrokeratodermia Variabilis, Mendes Da Costa Type
Progressive Symmetric Erythrokeratodermia
Erythrokeratodermia Figurata Variabilis
Greither'S Disease
Ekv-P
Erythrokeratodermia Variabilis Of Mendes Da Costa
Progressive Symmetrical Erythrokeratoderma Of Gottron
Progressive Diffuse Ppk
Progressive Diffuse Palmoplantar Keratoderma
Transgrediens Et Progrediens Ppk
Darier-Gottron Disease
Erythrokeratodermia Progressiva Symmetrica
Progressive Symmetric Erythrokeratodermia, Gottron Type
Congenital Familial Erythrokeratodermia Figurata In Plaques
Erythrokeratodermia Progressive Symmetric
Erythrokeratodermia Variabilis Mendes Da Costa Type
Ichthyosis, Congenital, Autosomal Recessive 4b
Harlequin Ichthyosis
Autosomal Recessive Congenital Ichthyosis 4b
Hi
Harlequin Fetus
ARCI4B
Ichthyosis Congenita, Harlequin Fetus Type
Harlequin Type Ichthyosis
'Harlequin Fetus'
Harlequin Type Ichthyosis Congenita
Harlequin Type Ichthyosis Fetalis
Harlequin Baby Syndrome
Ichthyosis Congenita, Harlequin Type
Ichthyosis Fetalis, Harlequin Type
Ichthyosis Congenita Harlequin Fetus Type
Ichthyosis, Harlequin
Ichthyosis, Congenital, Autosomal Recessive, Type 4b
Basal Cell Carcinoma
Basal Cell Cancer
Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin
Malignant Basal Cell Tumor
Basal Cell Tumor
Epithelioma Basal Cell
Malignant Basal Cell Neoplasm
Rodent Ulcer
Carcinoma Basal Cell
Neoplasms, Basal Cell
Basal Cell Carcinomas
Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma
Basalioma
Basal Cell Epithelioma Of Skin
Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin
Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site
Epidermolysis Bullosa Simplex 1a, Generalized Severe
Epidermolysis Bullosa Simplex, Dowling-Meara Type
Epidermolysis Bullosa Herpetiformis, Dowling-Meara Type
EBS1A
Ebsdm
Epidermolysis Bullosa Simplex Dowling-Meara Type
Epidermolysis Bullosa Simplex, Herpetiformis
Ebs-Dm
Epidermolysis Bullosa Simplex 1a, Dowling-Meara Type
Ebs-Gen Sev
Epidermolysis Bullosa Herpetiformis Dowling-Meara Type
Generalized Severe Epidermolysis Bullosa Simplex
Dowling-Meara Type Epidermolysis Bullosa Simplex
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form
Autosomal Dominant Generalized Ebs, Severe Form
Epidermolysis Bullosa Simplex Herpetiformis
Dm-Ebs
Epidermolysis Bullosa Simplex, Generalized Severe
Epidermolysis Bullosa Herpetiformis, Dowling-Meara
Epidermolysis Bullosa Herpetiformis Dowling-Meara
Cervical Squamous Cell Carcinoma
Squamous Cell Carcinoma Of The Cervix Uteri
Squamous Cell Carcinoma Of Cervix
Hair Follicle Neoplasm
Hair Matrix Neoplasm
Hair Matrix Tumour
Benign Chronic Pemphigus
Hailey-Hailey Disease
Pemphigus, Benign Familial
Familial Benign Pemphigus
Benign Familial Pemphigus
Familial Benign Chronic Pemphigus
BCPM
HHD
Benign Chronic Familial Pemphigus Of Hailey-Hailey
Pemphigus, Chronic, Benign
Autosomal Recessive Congenital Ichthyosis
Lamellar Ichthyosis
Congenital Ichthyosiform Erythroderma
Li
Congenital Nonbullous Ichthyosiform Erythroderma
Arci
Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma
Cie
Congenital Non-Bullous Ichthyosiform Erythroderma
Erythrodermic Ichthyosis
Nbcie
Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma
Collodion Baby
Ichthyosis, Lamellar
Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form
Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome
Ichthyoses, Lamellar
Nbie
Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis
Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital
Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital
Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma
Skin Squamous Cell Carcinoma
Squamous Cell Carcinoma Of Skin
Epidermoid Skin Carcinoma
Squamous Cell Carcinoma Of The Skin
Squamous Cell Epithelioma Of Skin
Cutaneous Squamous Cell Carcinoma
Scc - [Squamous Cell Carcinoma] Of Skin
Epidermolysis Bullosa Simplex Localized Type
Epidermolysis Bullosa Simplex, Weber-Cockayne Type
Weber-Cockayne Syndrome
Ebs-Loc
Epidermolysis Bullosa Simplex Of Palms And Soles
Epidermolysis Bullosa Simplex Weber-Cockayne Type
Epidermolysis Bullosa Simplex, Localized
Epidermolysis Bullosa Of Hands And Feet
Weber-Cockayne Type Epidermolysis Bullosa Simplex
Localized Epidermolysis Bullosa Simplex
Localized Ebs
Porokeratosis
Disseminated Superficial Actinic Porokeratosis
Dsap
Porokeratosis Of Mibelli
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细胞角蛋白7的表达在肿瘤及炎症中的意义 - 国际免疫学杂志
细胞角蛋白7的表达在肿瘤及炎症中的意义 - 国际免疫学杂志
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• 综述 •
细胞角蛋白7的表达在肿瘤及炎症中的意义
谢佳佳
郭晓华
国际免疫学杂志, 2016,39(1)
: 57-60. DOI: 10.3760/cma.j.issn.1673-4394.2016.01.013
摘要细胞角蛋白(Krt)作为一种中间丝,存在于所有的上皮细胞及部分非上皮细胞。主要作用是维持上皮细胞的机械稳定性和完整性。近年来细胞角蛋白的研究集中在肿瘤的诊断方面,即利用细胞角蛋白在上皮细胞表达的特异性,通过免疫组化技术,运用单克隆抗体进行比对分析,来确定肿瘤的分类、分型或者来源。其中Krt7是一个代表。探讨Krt7的作用,在上皮肿瘤中的分布,以及与细胞角蛋白20(Krt20)在上皮肿瘤中的联合表达情况,对肿瘤的诊断、转移性与原发肿瘤的鉴别等有重要意义。除此之外,Krt7还是一个炎性指标,发挥信号转导中的作用,参与炎症的发生发展,其表达也有利于对某些疾病早期及预后进行监测。
引用本文:
谢佳佳,
郭晓华.
细胞角蛋白7的表达在肿瘤及炎症中的意义
[J]
. 国际免疫学杂志, 2016, 39(1)
: 57-60.
DOI: 10.3760/cma.j.issn.1673-4394.2016.01.013.
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细胞角蛋白作为一种中间丝,存在于所有的上皮细胞及部分非上皮细胞。人细胞角蛋白有20种,它们分为两组:Ⅰ型,酸性细胞角蛋白(Moll数为9~20),28种;Ⅱ型,碱性细胞角蛋白(Moll数为1~8),26种[1]。I型和II型配对形成多样性的聚合物。作为细胞骨架的一部分,细胞角蛋白在维持上皮细胞的机械稳定性和完整性上起着重要的作用。此外,一些细胞角蛋白也有监管和参与细胞内信号通路的作用,如保护机体免受压力、促进伤口愈合等。它们的表达参与了细胞结构调控、生长、增殖和凋亡[1,2]。另外,细胞角蛋白在人类肿瘤中也呈现出特定的表达模式,尤其是Ⅰ型如K18、K19和K20,Ⅱ型如K5、K7、K8等,它们所在的上皮肿瘤及其转移瘤仍然保留原先的表达模式[3,4]。因而细胞角蛋白在肿瘤的免疫组化诊断、肿瘤的转移和分类以及亚型确定等方面起着重要作用。在众多细胞角蛋白中,Krt7是其中的一个代表,不仅因为它在肿瘤中的表达具有较高的特异性,其在炎症中也扮演着越来越重要的角色。
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贡献者信息
谢佳佳
510515 广州,南方医科大学病理生理学教研室
郭晓华
510515 广州,南方医科大学病理生理学教研室
通信作者
郭晓华
510515 广州,南方医科大学病理生理学教研室
Email:lanblue@fimmu.com
关键词
细胞角蛋白7;
肿瘤;
炎症;
基金项目
国家自然科学基金青年基金
(31300950)
教育部博士点博士学科点专项科研基金联合资助课题新教师类
(20124433120011)
历史
出版日期:2016-01-05
收稿日期:2015-07-19
Review
The meaning of keratin-7 expression in cancer and inflammation
XIE Jiajia, GUO Xiaohua
Published 2016-01-05
Cite as Int J Immunol, 2016, 39(1): 57-60. DOI: 10.3760/cma.j.issn.1673-4394.2016.01.013
Abstract
Keratins(Krt) are the typical intermediate filament proteins of epithelia.As part of the epithelial cytoskeleton, keratins are important for the mechanical stability and integrity of epithelial cells and tissues.Recent researches focus on the diagnostics value of carcinomas, for they have characteristic expression patterns in human tumors.Besides, immunohistochemistry(IHC) and monoclonal antibodies can be helpful to identify tumors’ classification as well as their origin.Different immunophenotypes are associated with different carcinomas.Keratin-7(Krt7) is one of a representative protein among those keratins.A particularly useful IHC panel consists of anti-keratin 7 and anti-keratin 20 (Krt7/Krt20) antibodies.In addition, Krt7 is also an inflammatory factor in organ damage, which has been shown to have diagnostic and prognostic value in particular diseases.
Key words:
Keratin-7; Cancer; Inflammation
Contributor Information
XIE Jiajia
Department of Pathaphysiology of Southern Medical University, Guangzhou 510515, China
GUO Xiaohua
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出 处:国际免疫学杂志2016年39卷1期
文 题:细胞角蛋白7的表达在肿瘤及炎症中的意义
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角蛋白(Keratin)介绍 - 知乎
角蛋白(Keratin)介绍 - 知乎切换模式写文章登录/注册角蛋白(Keratin)介绍毕合生物专注于生命科学、高端化学、药物中间体的自主研发,生产销售服务角蛋白分为表皮角蛋白和细胞角蛋白两种,这是根据其分部的部位而分的。表皮角蛋白包括皮肤表皮,消化道粘膜上皮、腺上皮甲状腺滤泡上皮、气管、支气管上 皮、肺泡上皮,角膜上皮、前列腺上皮等。细胞角蛋白包括颌下腺,胰腺,胸腺,细胞,肝细胞,肾小管细胞等。目前,应用上述细胞中间丝角蛋白作为抗原所制备 的抗体有单克隆抗体和多克隆抗体。角蛋白可有19个亚型 ,分为碱性和酸性,从1-8为碱性,9-19为酸性,分子量40-68不等,复层鳞上皮多为高分子量,单层上皮则多为低分子量,了解这些在临床的鉴别诊断 及抗体的应用中都 有极大的帮助。目前,检测这类特质的抗体很多,根据不同的克隆生产出不周类型的抗体。常用的抗体有:①单克隆小鼠抗人细胞角蛋白(Monoclonal mouse anti human cytokeratin)克隆为MNF116。该抗体应用范围,各类的冰冻切片,涂片,细胞培养片和经甲醛固定石蜡包埋的组织切片 。用本抗体检测的阳性组织有:鳞状上皮,甲状腺滤泡上皮消化道上皮,胰腺胆管上皮,肝胆管上皮,角膜上皮等以及发生于上述来源的肿瘤。应该注意的是有一些 肿瘤在检测时,可出现两种阳性物,即用两种抗体来检测如采用CK和Vimentin,可出现双向表达阳性的肿瘤有:癌内瘤,子宫内膜腺癌肺腺癌,上皮样内 瘤,滑膜内瘤,唾液腺肌上皮瘤,间皮瘤等等。这是由于在这些肿瘤中存在着两种不同的中间丝的缘故。应用该抗体检测呈阴性的肿瘤有:各种淋巴瘤,各类肌源性的肿瘤,恶性黑色素瘤,骨肿瘤,纤维组织肿瘤,脂肪肿瘤,神经组织肿瘤和精原细胞瘤等。在检测某些肿瘤时,常可出现这样的问题,在同一张切片上,同样的鳞状细胞癌的细胞,有的抗原表达为强阳性,有的表达为中度阳性性,有的表达为弱阳性,甚至有的呈阴性。这主要是由于各种细胞处于增生的不同阶段,细胞分泌的抗原量不同,因而表达 也不同。该抗体可用各种方法检测,但最好用真空负压LSAB法。产品说明书注明该抗体稀释度1:50至1:100,我们使用为1:100。②单克隆小鼠抗人细胞角蛋白,克隆为LP34。该抗体的使用范围,检测各种组织基本上与①号抗体相同,但效果不如①号。③单克隆小鼠抗 人细胞角蛋白,克隆为35BH11。该抗体的特点是:A,可检测几乎所有的非鳞状上皮包括卵巢腺癌,胃肠道腺癌,甲状腺癌,肝癌, 子宫癌,肾癌等。B、不与鳞状上皮起反应。C、对膀胱癌,鼻咽癌,胸腺癌等部分阳性。但是,该 抗体只能用于冰冻切片 ,涂片和细胞培养片。不能用于石蜡切片 。④单克隆小鼠抗 人细胞角蛋白,克隆34BE12。该 抗体属于高分子量类型,它可检测鳞状上皮管上皮和 复层上皮的组织及其来源的肿瘤。适用范围:可用于各种类型的切片 。作者:毕合生物公众号:毕合生物发布于 2023-03-24 14:05・IP 属地吉林生物化学赞同添加评论分享喜欢收藏申请
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角蛋白 7(KRT7)基因 | MCE
角蛋白 7(KRT7)基因 | MCE
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Gene
KRT7 - keratin 7 Gene
KRT7 - keratin 7 Gene
基因
蛋白
疾病
相关产品
直系同源
中文名称:角蛋白 7
种属: Homo sapiens
同用名: K7; CK7; SCL; K2C7
基因 ID: 3855
|
基因类型: protein coding
关于 KRT7
Cytogenetic location: 12q13.13
Genomic coordinates (GRCh38): 12:52,233,243-52,255,853 (from NCBI)
This gene has 13 transcripts (splice variants), 94 orthologues and 68 paralogues. Biased expression in thyroid (RPKM 146.2), placenta (RPKM 75.4) and 5 other tissues.
功能概要
该基因编码的蛋白质是角蛋白基因家族的一员。 II 型细胞角蛋白由碱性或中性蛋白组成,这些蛋白排列成对异型角蛋白链,在单层和复层上皮组织分化过程中共同表达。这种 II 型细胞角蛋白在内脏器官腔内衬的简单上皮细胞以及腺管和血管中特异性表达。编码 II 型细胞角蛋白的基因聚集在染色体 12q12-q13 区域。选择性剪接可能会导致多种转录本变异;然而,并非所有变体都得到了充分描述。[RefSeq 提供,2008 年 7 月]
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
KRT7 基因产物(1)
mRNA
Protein
Name
NM_005556.4
NP_005547.3
keratin, type II cytoskeletal 7
KRT7 蛋白结构
Filament
Filament: Intermediate filament protein (90 - 402)
0
100
200
300
400
469 a.a.
蛋白主名
其他名称
keratin, type II cytoskeletal 7
CK-7
关联疾病
疾病名称
别名
Pseudomyxoma Peritonei
Adenomucinosis
Gelatinous Ascites
Pmp
Mucinous Ascites
Syndrome Of Pseudomyxoma Peritonei
Bile Duct Adenoma
Cholangioadenoma
Adenoma Bile Duct
Adenoma, Bile Duct
Cystadenoma
Cystoma
Craniopharyngioma
Mucinous Cystadenocarcinoma
Cystadenocarcinoma, Mucinous
Pseudomucinous Cystadenocarcinoma
Cystadenocarcinoma Mucinous
Paget Disease, Extramammary
Extramammary Paget Disease
Cutaneous Paget'S Disease
Extramammary Paget'S Disease
Paget Disease Extramammary
Cutaneous Paget Disease
Paget'S Disease Of Skin
Empd
Extramammary Pagets Disease
Signet Ring Cell Adenocarcinoma
Signet Ring Cell Carcinoma
Carcinoma, Signet Ring Cell
Signet Ring Carcinoma
Carcinoma Signet Ring Cell
Adenosquamous Carcinoma
Adenosquamous Cell Carcinoma
Mixed Adenocarcinoma And Squamous Carcinoma
Carcinoma Adenosquamous
Carcinoma, Adenosquamous
Oncocytoma
Oxyphilic Adenoma
Follicular Adenoma, Oxyphilic Cell
Adenoma, Oxyphilic
Hurthle Cell Tumor
Oncocytic Neoplasm
Hidrocystoma
Apocrine Cystadenoma
Eccrine Hidrocystoma
Eccrine Cystadenoma
Eccrine Hidrocystoma Of Skin
Apocrine Adenoma
Appendix Cancer
Appendiceal Neoplasms
Cancer Of The Appendix
Malignant Neoplasm Of Appendix Vermiformis
Malignant Tumor Of Appendix
Malignant Tumor Of The Appendix
Malignant Neoplasm Of Appendix
Carcinoma Of The Appendix
Sertoli-Leydig Cell Tumor
Sertoli-Leydig Cell Tumors
Androblastoma Of Ovary
Arrhenoblastoma
Arrhenoblastoma Of Ovary
Sertoli-Leydig Cell Tumor Of The Ovary
Sertoli-Leydig Cell Tumor Of Intermediate Differentiation
Sertoli-Leydig Cell Tumor Of Ovary
Duodenum Cancer
Duodenal Cancer
Duodenal Neoplasms
Cancer Of Duodenum
Duodenal Neoplasm
Duodenal Carcinoma
Cancer, Duodenal
Malignant Neoplasm Of Duodenum
Cervical Adenocarcinoma
Adenocarcinoma Cervix Uteri
Adenocarcinoma Of Cervix
Adenocarcinoma Of The Uterine Cervix
Adenocarcinoma Of The Cervix Uteri
Mammary Paget'S Disease
Paget'S Disease
Mammary Paget Disease
Paget'S Disease Of The Breast
Paget Disease Of The Breast
Paget'S Disease Of The Nipple
Paget'S Disease, Mammary
Paget Cell Neoplasm
Paget Disease Of The Nipple
Pagets Disease Mammary
Osteitis Deformans
Secretory Meningioma
Meningioma
Thymic Carcinoma
Malignant Thymoma
Thymoma, Malignant
Pancreatic Ductal Carcinoma
Carcinoma, Pancreatic Ductal
Malignant Neoplasm Of Duct Of Wirsung
Pancreatic Duct Cancer
Carcinoma Pancreatic Ductal
Dysgerminoma
Sweat Gland Cancer
Sweat Gland Carcinoma
Malignant Neoplasm Of Sweat Gland
Malignant Tumor Of The Sweat Gland
Carcinoma Of The Sweat Gland
Primary Malignant Neoplasm Of Sweat Gland
Sweat Gland Neoplasms
Neuroendocrine Carcinoma
Neuroendocrine Cancer
Carcinoma Neuroendocrine
Carcinoma, Neuroendocrine
Benign Teratoma
Dermoid Cyst
Cystic Dermoid Choristoma
Dermoid Choristoma
Mature Cystic Teratoma
Dermoid Tumour
Teratoma, Benign
Dermoid Cyst Of Ovary
Epithelioid Sarcoma
Epithelioid Cell Sarcoma
Sarcoma Epithelioid
Sarcoma, Epithelioid
Trachea Carcinoma
Pancoast Tumor
Carcinoma Of The Trachea
Pancoast'S Tumor
Malignant Superior Sulcus Tumor
Malignant Superior Sulcus Tumour
Pancoast Tumour
Pancoast'S Syndrome
Pancoast'S Tumour
Pulmonary Sulcus Tumor
Pulmonary Sulcus Tumour
Superior Pulmonary Sulcus Syndrome
Pancoast Syndrome
Bladder Adenocarcinoma
Adenocarcinoma Of Bladder
Adenocarcinoma Of The Urinary Bladder
Bladder Adenocarcinoma, Not Otherwise Specified
Adenocarcinoma Bladder
Large Cell Carcinoma
Carcinoma, Large Cell
Carcinoma Large Cell
Carcinosarcoma
Mixed Tumor, Mullerian
Malignant Mixed Mesodermal Tumor
Malignant Mixed Mullerian Tumor
Mmmt
Mixed Tumor, Mesodermal
Mesodermal Mixed Tumor
Mixed Mesodermal Tumor
Mullerian Mixed Tumor
Mixed Mullerian Tumor
Malignant Mixed Müllerian Tumor
Mixed Müllerian Tumor
Mixed Tumor Mullerian
Mixed Tumor, Not Otherwise Specified
Bronchiolo-Alveolar Adenocarcinoma
Bronchioloalveolar Carcinoma
Bronchioalveolar Lung Carcinoma
Minimally Invasive Lung Adenocarcinoma
Carcinoma Bronchioloalveolar
Adenocarcinoma, Bronchiolo-Alveolar
Bronchioloalveolar Adenocarcinoma
Papillary Craniopharyngioma
Craniopharyngioma, Papillary
Papillary Rathke'S Pouch Tumor
Craniopharyngioma Papillary
Anal Canal Carcinoma
Anal Canal Cancer
Anal Canal And Perianal Gland Carcinoma
Carcinoma Of The Anal Canal
Carcinoma Of Anal Canal
Transitional Cell Carcinoma
Transitional Cell Neoplasm
Carcinoma, Transitional Cell
Transitional Carcinoma
Transitional Cell Tumor
Urothelial Cell Carcinoma
Carcinoma Transitional Cell
Transitional Cell Carcinoma Of Bladder
Ovarian Brenner Tumor
Benign Ovarian Brenner Tumor
Brenner Tumor
Benign Ovarian Brenner Tumour
Ovarian Brenner Tumour
Brenner Tumor Of Ovary
Benign Brenner Tumor
Thymus Cancer
Thymic Neoplasm
Thymic Tumor
Thymus Neoplasm
Thymus Neoplasms
Malignant Neoplasm Of Thymus
Neoplasm Of Thymus
Thymic Neoplasms
Thymoma, Familial
Thymic Carcinoma
Thymoma, Type C
Cancer Of Thymus
Malignant Tumour Of Thymus
Primary Malignant Neoplasm Of Thymus
Thymic Glandular Cancer
Thymus Gland Cancer
Acinar Cell Carcinoma
Acinic Cell Carcinoma
Acinic Cell Tumor
Carcinoma Acinar Cell
Carcinoma, Acinar Cell
Acinar Cell Tumor
Barrett Esophagus
Barrett'S Esophagus
Barrett Esophagus/Esophageal Adenocarcinoma
Barrett Metaplasia
Barrett'S Ulcer Of Esophagus
Ulcerative Esophagitis
Barrett'S Esophagus With Esophagitis
Barrett'S Oesophagus
Barretts Syndrome
Barrett Syndrome
BE
Peptic Ulcer Of Esophagus
Adenocarcinoma Of Esophagus
Bowen'S Disease
Bowens Disease
Papillary Carcinoma
Carcinoma, Papillary
Carcinoma Papillary
Ovarian Mucinous Neoplasm
Ovarian Mucinous Tumor
Malignant Ovarian Mucinous Neoplasm
Mucinous Tumor Of Ovary
Malignant Ovarian Mucinous Tumor
Papillary Adenocarcinoma
Infiltrating And Papillary Adenocarcinoma
Infiltrating Papillary Adenocarcinoma
Adenocarcinoma Papillary
Adenocarcinoma, Papillary
Brooke-Spiegler Syndrome
Cyld Cutaneous Syndrome
Spiegler-Brooke Syndrome
Familial Cylindromatosis
BRSS
Bss
Sbs
Multiple Familial Trichoepithelioma
Ancell-Spiegler Cylindromas
Familial Multiple Trichoepithelioma
Trichoepithelioma
Fc
Mft
Multiple Familial Trichoepitheliomas
Ccs
Turban Tumor Syndrome
Schilbach-Rott Syndrome
Eccrine Dermal Cylindroma
Familial Multiple Trichoepitheliomata
Vulva Adenocarcinoma
Adenocarcinoma Of The Vulva
Adenocarcinoma Of Vulva
Krukenberg Carcinoma
Krukenberg Tumor
Krukenberg Neoplasm
Krukenberg'S Tumor
Lymphoepithelioma-Like Carcinoma
Lymphoepithelial Carcinoma
Nasopharyngeal Type Undifferentiated Carcinoma
Ampulla Of Vater Cancer
Ampulla Of Vater Carcinoma
Ampullary Carcinoma
Malignant Tumour Of Ampulla Of Vater
Carcinoma Of Ampulla Of Vater
Carcinoma Of The Ampulla Of Vater
Ampulloma
Borst-Jadassohn Intraepidermal Carcinoma
Intraepidermal Epithelioma Of Jadassohn
Bowen'S Disease, Clonal
Vulval Paget'S Disease
Paget'S Disease Of Vulva
Vulval Paget Disease
Vulvar Paget'S Disease
Extramammary Paget Disease Of Vulva
Teratoma
Teratomas
Papillary Adenoma
Glandular Papilloma
Adenoma
Bile Duct Cancer
Bile Duct Carcinoma
Extrahepatic Bile Duct Carcinoma
Carcinoma Of Extrahepatic Bile Duct
Extrahepatic Bile Duct Cancer
Bile Duct Neoplasms
Bile Duct Tumor
Ca Extrahepatic Bile Ducts
Malignant Neoplasm Of The Extrahepatic Bile Duct
Bile Duct Extrahepatic Carcinoma
Malignant Tumor Of Extrahepatic Bile Duct
Sex Cord-Gonadal Stromal Tumor
Sex Cord-Gonadal Stromal Tumour
Sex Cord Stromal Tumour
Sex Cord-Stromal Neoplasm
Specialized Gonadal Neoplasm
Specialized Gonadal Tumor
Specialized Gonadal Tumour
Sex Cord-Gonadal Stromal Tumors
Sex Cord-Stromal Tumor
Malignant Testicular Sex Cord-Stromal Tumor
Sex Cord Stromal Tumor Of Testis
Anal Canal Adenocarcinoma
Adenocarcinoma Of The Anal Canal
Adenocarcinoma Of Anal Canal
Biliary Tract Benign Neoplasm
Extrahepatic Bile Duct Neoplasm
Neoplasm Of Extrahepatic Bile Ducts
Tumor Of The Extrahepatic Bile Duct
Intestinal Perforation
Perforation Of Intestine
Adenomatoid Tumor
Adenomatoid Tumour
Benign Localised Epithelial Mesothelioma
Benign Localized Epithelial Mesothelioma
Ceruminous Adenocarcinoma
Seminal Vesicle Adenocarcinoma
Gallbladder Adenocarcinoma
Adenocarcinoma Of The Gallbladder
Carcinoma Of The Gallbladder
Bladder Urachal Carcinoma
Urachal Cancer
Urachal Carcinoma
Urachus Cancer
Malignant Tumor Of Urachus
Ceruminoma
Ceruminous Adenoma
External Auditory Canal Ceruminous Adenoma
Cystitis Cystica
Cystadenocarcinoma
Necrotizing Sialometaplasia
Sialometaplasia, Necrotizing
Chordoma
CHDM
Notochordoma
Notochordal Sarcoma
Chordoma, Susceptibility To
Chordocarcinoma
Chordoepithelioma
Bladder Benign Neoplasm
Mucinous Adenocarcinoma
Mucin-Producing Adenocarcinoma
Mucin-Secreting Adenocarcinoma
Mucin-Secreting Carcinoma
Mucous Carcinoma
Pseudomyxoma Peritonei With Unknown Primary Site
Adenocarcinoma, Mucinous
Intrahepatic Bile Duct Adenoma
Adenoma Of Intrahepatic Bile Duct
Adenoma Of The Intrahepatic Bile Duct
Warthin Tumor
Papillary Cystadenoma Lymphomatosum
Adenolymphoma
Mucinous Ovarian Cystadenoma
Mucinous Cystadenoma Of Ovary
Ovarian Mucinous Cystadenoma
Nasal Cavity Cancer
Nasal Cavity Carcinoma
Malignant Neoplasm Of Nasal Cavities
Malignant Tumor Of The Nasal Cavity
Cancer Of Nasal Cavity
Carcinoma Of Nasal Cavity
Malignant Neoplasm Of Nasal Cavity
Neoplasm Of Nasal Cavity
Urinary Bladder Villous Adenoma
Villous Adenoma Of Urinary Bladder
Bladder Villous Adenoma
Eccrine Adenocarcinoma
Adenoid Basal Cell Carcinoma
Skin Adenoid Basal Cell Carcinoma
Basal Cell Carcinoma - Adenoid
Intestinal Obstruction
Inspissated Milk Syndrome
Milk Curd Syndrome
Appendix Disease
Disorder Of Appendix
Lung Benign Neoplasm
Lung Neoplasms
Tumor Of The Lung
Lung Tumor
Laryngeal Adenoid Cystic Carcinoma
Adenoid Cystic Carcinoma Of Larynx
Gallbladder Signet Ring Cell Adenocarcinoma
Signet Ring Cell Carcinoma Of The Gallbladder
Cystic Teratoma
Dermoid Cyst
Benign Teratoma
Benign Mesothelioma
Mesothelioma
Benign Tumor Of Mesothelium
Adenomatoid Tumor
Adenoid Cystic Carcinoma
Adenocystic Carcinoma
Cribriform Carcinoma
Cylindroma
Carcinoma Adenoid Cystic
Carcinoma, Adenoid Cystic
Adenoid Cystic Carcinoma Of Salivary Gland
Eccrine Dermal Cylindroma
Carcinoma, Cribriform
Pancreatic Serous Cystadenocarcinoma
Serous Cystadenocarcinoma Of Pancreas
Gastric Diffuse Adenocarcinoma
Diffuse Gastric Adenocarcinoma
Carcinoma, Diffuse Type
Sarcoma, Synovial
Synovial Sarcoma
Synovialosarcoma
Synovial Cell Sarcoma
Sarcoma Synovial
Ureter, Cancer Of
Ureter Carcinoma
Ureter Cancer
Ureteral Neoplasms
Malignant Neoplasm Of Ureter
Malignant Tumour Of Ureter
Malignant Ureteral Tumor
Ureteral Carcinoma
Ureteral Neoplasm
Merkel Cell Carcinoma
Trabecular Adenocarcinoma
Cutaneous Neuroendocrine Carcinoma
Trabecular Carcinoma
Carcinoma, Merkel Cell
Merkel Cell Cancer
Merkle Tumors
Mcc
Carcinoma Merkel Cell
Sweat Gland Disease
Sweat Gland Diseases
Salivary Gland Carcinoma
Salivary Gland Cancer
Malignant Neoplasm Of Salivary Gland
Salivary Gland Neoplasms
Leukoplakia Of Penis
Penile Leukoplakia
Balanitis Xerotica Obliterans
Kraurosis Of Penis
Scrotum Paget'S Disease
Paget'S Disease Of Scrotum
Scrotum Paget Disease
Paget Disease Of The Scrotum
Cervical Basaloid Squamous Cell Carcinoma
Cervical Basaloid Carcinoma
Ovarian Benign Neoplasm
Benign Ovarian Neoplasm
Renal Oncocytoma
Oncocytoma, Renal
Oncocytoma Of Kidney
Renal Epithelial Oncocytic Tumor
Oncocytoma Kidney
Oncocytoma Renal
Kidney Oncocytoma
Metanephric Adenoma
Adenoma
Acinar Cell Adenoma
Adenomas
Acinic Cell Adenoma
Renal Adenoma
Renal Cell Adenoma
Apocrine Sweat Gland Neoplasm
Apocrine Tumor
Apocrine Neoplasm
Endodermal Sinus Tumor
Yolk Sac Tumor
Endodermal Sinus Tumour
Hepatoid Yolk Sac Tumour
Infantile Embryonal Carcinoma
Yolk Sac Neoplasm
Yolk Sac Tumour
Eosinophilic Variant Of Chromophobe Renal Cell Carcinoma
Ureteral Benign Neoplasm
Neoplasm Of Ureter
Ureteral Tumor
Cancer Of The Ureter
Malignant Tumour Of Ureter
Ureteric Cancer
Primary Malignant Neoplasm Of Ureter
Small Intestine Cancer
Small Intestine Carcinoma
Cancer Of The Small Bowel
Small Bowel Cancer
Small Intestinal Carcinoma
Malignant Neoplasms Of The Small Intestine
Small Bowel Tumors
Malignant Tumor Of Small Intestine
Neoplasm Of Small Intestine
Urethral Diverticulum
Urethral Sacculation
Mesenchymal Chondrosarcoma
Chondrosarcoma, Mesenchymal
Chondrosarcoma Mesenchymal
Epithelial-Myoepithelial Carcinoma
Clear Cell Adenoma
Adenomyo-Epithelioma
Clear Cell Carcinoma
Emc
Epithelial Myoepithelial Carcinoma
Glycogen-Rich Adenocarcinoma
Glycogen-Rich Adenoma
Monomorphic Clear Cell Tumor
Tubular Solid Adenoma
Adenocarcinoma, Clear Cell
Anal Gland Adenocarcinoma
Adenocarcinoma Of Anal Ducts
Adenocarcinoma Of Anal Gland
Anal Glands Adenocarcinoma
Adenocarcinoma Of Anal Glands
Tubular Adenocarcinoma
Tubular Carcinoma
Adenocarcinoma Tubular
Adenocarcinoma, Tubular
Spindle Cell Sarcoma
Sarcoma
Sarcoma Spindle Cell
Sarcoma, Spindle Cell
Sarcoma - Category
Vulva Cancer
Vulvar Carcinoma
Malignant Neoplasm Of Vulva
Vulva Carcinoma
Carcinoma Of Vulva
Vulvar Cancer
Vulval Cancer
Vulvar Neoplasms
Ca Vulva
Malignant Tumor Of Vulva
Malignant Vulvar Tumor
Neoplasm Of Vulva
Vulval Neoplasm
Vulvar Neoplasm
Vulvar Tumor
Cancer Of Vulva
Malignant Tumour Of Vulva
Sertoli Cell Tumor
Tubular Androblastoma
Malignant Spiradenoma
Malignant Eccrine Spiradenoma
Eccrine Spiradenoma, Malignant
Mes
Kidney Benign Neoplasm
Renal And Ureteral Tumor
Benign Kidney Neoplasm
Sweat Gland Benign Neoplasm
Neoplasm Of Sweat Gland
Sweat Gland Tumor
Tumor Of The Sweat Gland
Sweat Gland Neoplasms
Sweat Gland Neoplasm
Mucoepidermoid Carcinoma
Mec
Salivary Gland Mucoepidermoid Carcinoma
C3772
Carcinoma Mucoepidermoid
Carcinoma, Mucoepidermoid
Linitis Plastica
Leather-Bottle Stomach
Hemosiderosis
Haemosiderosis
Iron Overload
Renal Cell Carcinoma, Nonpapillary
Renal Cell Carcinoma
RCC
Nonpapillary Renal Cell Carcinoma
Clear Cell Renal Cell Carcinoma
Hypernephroma
Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic
Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma
Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic
Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma
Renal Clear Cell Carcinoma
Ccrcc
Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell
Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell
Clear Cell Kidney Carcinoma
Clear Cell Rcc
Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma
Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma
Crcc
Renal Cell Carcinoma Non-Papillary
Carcinoma Renal Cell
Renal Cell Cancer
Carcinoma, Renal Cell, Nonpapillary
Jejunal Adenocarcinoma
Glandular Cystitis
Cystitis Glandularis
Ovarian Mucinous Adenocarcinoma
Mucinous Carcinoma Of Ovary
Spiradenoma
Eccrine Spiradenoma
Benign Eccrine Spiradenoma
Eccrine Spiradenoma Of Skin
Es
Eccrine Spiradenoma, Benign
Adenocarcinoma
Adenocarcinomas
Adenoacanthoma Of Unspecified Site
Adenocarcinoid Of Unspecified Site
Adenocarcinoid Tumour Of Unspecified Site
Adenocarcinoma And Carcinoid Combined Of Unspecified Site
Adenocarcinoma Nos
Mucinous Bronchioloalveolar Adenocarcinoma
Bronchiolo-Alveolar Carcinoma, Mucinous
Appendix Adenocarcinoma
Cystadenocarcinoma
Mucinous Adenocarcinoma
Adenocarcinoma Of Appendix
Appendiceal Adenocarcinoma
Adenocarcinoma Of The Appendix
Colonic Type Adenocarcinoma
Nonmucinous Adenocarcinoma
Ovary Neuroendocrine Neoplasm
Neuroendocrine Tumor Of Ovary
Eyelid Carcinoma
Carcinoma Of The Eyelid
Mucinous Adenofibroma
Cholangiocarcinoma
Cholangiocarcinoma, Susceptibility To
Extrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma
Chlc
Chlc, Susceptibility To
Cc
Cholangiocarcinoma Of Biliary Tract
Cholangiocellular Carcinoma
Distal Cholangiocarcinoma
Perihilar Cholangiocarcinoma
Bile Duct Cancer
Cca
Adult Primary Cholangiocellular Carcinoma
Bile Duct Carcinoma
Eccrine Sweat Gland Cancer
Malignant Eccrine Skin Neoplasm
Malignant Eccrine Tumor
Urethral Villous Adenoma
Anus Adenocarcinoma
Adenocarcinoma Of Anus
Adenocarcinoma Of The Anus
Nephrogenic Adenoma
Nephrogenic Metaplasia
Papillary Cystadenocarcinoma
Cystadenocarcinoma, Papillary
Angiomyolipoma
Angiomyolipoma Of Kidney
Cholangiolocellular Carcinoma
Nephrogenic Adenoma Of Urinary Bladder
Nephrogenic Adenoma Of The Urinary Bladder
Basaloid Squamous Cell Carcinoma
Basaloid Carcinoma
Cystadenofibroma
Bartholin'S Gland Adenocarcinoma
Bartholin Gland Adenocarcinoma
Adenocarcinoma Of Bartholin'S Gland
Adenocarcinoma Of The Bartholin'S Gland
Pancreatic Foamy Gland Adenocarcinoma
Urethral Benign Neoplasm
Urethral Neoplasms
Neoplasm Of Urethra
Neoplasm. Urethra
Urethral Neoplasm
Urethral Carcinoma
Malignant Neoplasm Of Urethra
Anal Fistula
Anorectal Fistula
Rectal Fistula
Allingham Ulcer
Perianal Fistula
Fistula In Ano
Anorectum Fistula
Mixed Cell Type Cancer
Malignant Mixed Neoplasm
Malignant Mixed Tumor
Mixed Neoplasm
Mixed Tumor, Malignant
Malignant Mixed Cancer
Mixed Tumor
Malignant Mixed Tumor, Not Otherwise Specified
Mixed Salivary Gland Tumor
Mixed Tumor, Not Otherwise Specified
Nephrogenic Adenofibroma
Metanephric Adenofibroma
Mucinous Cystadenofibroma
Middle Ear Adenoma
Adenoma Of Middle Ear
Adenoma Of The Middle Ear
Auditory System Benign Neoplasm
Biliary Atresia
Congenital Biliary Atresia
Isolated Biliary Atresia
Isolated Atresia Of Bile Ducts
Non-Syndromic Biliary Atresia
Atresia Of Bile Duct
Biliary Atresia, Congenital
Atresia Of Bile Ducts
Bile Duct Atresia
Congenital Bile Duct Atresia
Ba - [Biliary Atresia]
Impervious Bile Duct
Atresia Of Common Duct
Biliary Duct Atresia
Bile Ductal Atresia
Cystic Duct Atresia
Hepatoblastoma
Syringocystadenoma Papilliferum
Fistulous Vegetative Verrucous Hydradenoma
Papillary Syringadenoma
Naevus Syringocystadenomatosus Papilliferus
Papillary Syringocystadenoma
Scap
Syringadenoma Papilliferum
Papillary Hidradenoma
Apocrine Adenoma
Tubular Apocrine Adenoma
Urethra Cancer
Cancer Of Urethra
Malignant Tumour Of Urethra
Malignant Urethral Neoplasm
Urethral Ca
Endometrial Transitional Cell Carcinoma
Chronic Cystitis
Breast Mucinous Carcinoma
Mucinous Carcinoma Of Breast
Invasive Mucinous Breast Carcinoma
Bile Duct Signet Ring Cell Carcinoma
Extrahepatic Bile Duct Signet Ring Cell Carcinoma
Bladder Signet Ring Cell Adenocarcinoma
Signet Ring Cell Adenocarcinoma Of Bladder
Urinary Bladder Signet Ring Adenocarcinoma
Craniopharyngioma
Neoplasm Of Rathke'S Pouch
Adamantinomatous Tumor
Craniopharyngeal Duct Tumor
Dysodontogenic Epithelial Tumor
Rathke'S Pouch Tumor
Ovarian Seromucinous Carcinoma
Mixed Epithelial Carcinoma Of Ovary
Ovary Mixed Epithelial Carcinoma
Fibroma
Pancreatic Serous Cystic Neoplasm
Pancreatic Serous Neoplasm
Endosalpingiosis
Endometrial Cancer
Endometrial Carcinoma
Endometrial Neoplasm
Malignant Neoplasm Of Endometrium
Endometrioid Carcinoma
Endometrial Neoplasms
Carcinoma, Endometrioid
Endometrial Cancer, Familial
Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To
Endometrial Ca
Malignant Endometrial Neoplasm
Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium
Tumor Of Endometrium
Carcinoma Of The Endometrium
Endometrioid Carcinoma Of Female Reproductive System
ENDMC
Carcinoma Endometrioid
Endometrial Cancers
Cancer, Endometrial
Uterine Corpus Cancer
Hepatoid Adenocarcinoma
Epididymis Adenocarcinoma
Adenocarcinoma Of The Epididymis
Epididymis Cancer
Malignant Tumor Of Epididymis
Malignant Epididymal Tumor
Malignant Neoplasm Of Epididymis
Neoplasm Of Epididymis
Ovarian Cancer
Ovarian Carcinoma
Ovarian Neoplasm
Malignant Tumour Of Ovary
Cancer Of The Ovary
Epithelial Ovarian Cancer
Neoplasm Of Ovary
Ovarian Neoplasms
Ovarian Cancers
Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic
Malignant Ovarian Tumor
Ovary Neoplasm
Primary Ovarian Cancer
Tumor Of The Ovary
Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary
Ovarian Malignant Tumor
OC
Ovarian Carcinomas
Cancer, Ovarian
Cancer Of Ovary
Ovary Cancer
Ca Ovary
Cervical Mucinous Adenocarcinoma
Adenosquamous Gallbladder Carcinoma
Adenosquamous Carcinoma Of Gallbladder
Adenosquamous Carcinoma Of The Gallbladder
Gallbladder Adenosquamous Carcinoma
Sarcomatoid Renal Cell Carcinoma
Renal Cell Carcinoma, Spindle Cell
Papillary Transitional Carcinoma
Papillary Transitional Cell Carcinoma
Anus Basaloid Carcinoma
Basaloid Carcinoma Of The Anus
Anal Basaloid Carcinoma
Gallbladder Cancer
Gallbladder Carcinoma
Gallbladder Neoplasm
Malignant Neoplasm Of Gallbladder
Malignant Tumour Of Gallbladder
Gallbladder Ca
Localized Malignant Gallbladder Neoplasm
Malignant Tumor Of The Gallbladder
Tumor Of The Gallbladder
Cancer Of The Gallbladder
Carcinoma Gallbladder
Carcinoma Of Gallbladder
Gallbladder Neoplasms
Malignant Neoplasm Of Gallbladder Localized
Cancer Of Gallbladder
Primary Malignant Neoplasm Of Gallbladder
Lacrimal Gland Carcinoma
Lacrimal Gland Cancer
Carcinoma Of The Lacrimal Gland
Malignant Neoplasm Of Lacrimal Gland
Malignant Tumour Of Lacrimal Gland
Neoplasm Of Lacrimal Gland
Tumor Of The Lacrimal Gland
Malignant Tumor Of Lacrimal Gland
Sigmoid Neoplasm
Sigmoid Neoplasms
Neoplasm Of Sigmoid Colon
Tumor Of Sigmoid Colon
Inverted Transitional Papilloma
Transitional Papilloma, Inverted
Transitional Cell Papilloma, Inverted
Myoepithelial Carcinoma
Malignant Myoepithelioma
Myoepithelioma Carcinoma
Adenoid Squamous Cell Carcinoma
Acantholytic Squamous Cell Carcinoma
Adenocarcinoma With Squamous Metaplasia
Adenoacanthoma
Pseudoglandular Squamous Carcinoma
Ovarian Endodermal Sinus Tumor
Endodermal Sinus Tumor Of Ovary
Ovarian Yolk Sac Tumor
Endodermal Sinus Tumour Of Ovary
Ovarian Endodermal Sinus Tumour
Ovarian Yolk Sac Tumour
Renal Pelvis Adenocarcinoma
Adenocarcinoma Of Renal Pelvis
Adenocarcinoma Of The Kidney Pelvis
Ovarian Mucinous Adenofibroma
Ovarian Mucinous Cystadenofibroma
Rete Testis Neoplasm
Rete Testis Adenocarcinoma
Adenocarcinoma Of Rete Testis
Adenocarcinoma Of The Rete Testis
Urethra Adenocarcinoma
Adenocarcinoma Of The Urethra
Urethral Adenocarcinoma
Breast Papillary Carcinoma
Breast Solid Papillary Carcinoma
Papillary Carcinoma Of Breast
Papillary Carcinoma Of The Breast
Solid Papillary Carcinoma Of The Breast
Urethra Clear Cell Adenocarcinoma
Clear Cell Adenocarcinoma Of The Urethra
Urethral Clear Cell Adenocarcinoma
Chromophil Adenoma Of The Kidney
Papillary Adenoma Of The Kidney
Breast Hemangiopericytoma
Hemangiopericytoma Of The Breast
Ampulla Of Vater Adenocarcinoma
Adenocarcinoma Of Ampulla Of Vater
Ampullary Adenocarcinoma
Malignant Peripheral Nerve Sheath Tumor
Mpnst
Malignant Neurilemmoma
Neurofibrosarcoma
Malignant Neurofibroma
Malignant Schwannoma
Neurogenic Sarcoma
Schwannoma, Malignant
Malignant Neoplasm Of The Peripheral Nerve Sheath
Malignant Peripheral Nerve Sheath Tumors
Pleomorphic Carcinoma
Oncocytic Breast Carcinoma
Appendiceal Neoplasm
Appendix Neoplasm
Neoplasm Of Appendix
Appendiceal Neoplasms
Appendiceal Cancer
Appendix Cancer
Malignant Neoplasm Of Appendix Vermiformis
Malignant Tumour Of Appendix
Cystitis
Infective Cystitis
Urocystitis
Pyocystitis
Sensory Organ Benign Neoplasm
Sebaceous Adenocarcinoma
Sebaceous Carcinoma
Adenocarcinoma Of The Sebaceous Gland
Malignant Neoplasm Of Sebaceous Gland
Malignant Sebaceous Tumor
Adenocarcinoma, Sebaceous
Malignant Sebaceous Neoplasm
Sebaceous Gland Neoplasms
Large Cell Neuroendocrine Carcinoma
Mesothelioma, Malignant
Malignant Mesothelioma
Pleural Mesothelioma
MESOM
Mesothelioma, Somatic
Advanced Malignant Mesothelioma
Asbestos-Related Malignant Mesothelioma
Diffuse Malignant Mesothelioma
Malignant Tumor Of Mesothelium
Malignant Mesothelioma, Susceptibility To
Mesothelioma Diffuse Malignant
Mesothelioma
Malignant Pleural Mesothelioma
Clear Cell Basal Cell Carcinoma
Skin Clear Cell Basal Cell Carcinoma
Aortic Malignant Tumor
Aortic Malignant Neoplasm
Malignant Aortic Neoplasm
Apocrine Adenocarcinoma
Apocrine Carcinoma
Apocrine Gland Carcinoma
Carcinoma Of The Apocrine Gland
Carcinoma Of Apocrine Gland
Transitional Papilloma
Transitional Cell Papilloma
Transitional Cell Papilloma, Benign
Fibrolamellar Carcinoma
Fibrolamellar Hepatocellular Carcinoma
Fhcc
Fibrolamellar Hepatocarcinoma
Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor
Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis
Fl-Hcc
Fibrolamellar Oncocytic Hepatoma
Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Gastric Signet Ring Cell Adenocarcinoma
Signet Ring Cell Gastric Adenocarcinoma
Signet Ring Cell Adenocarcinoma Of The Stomach
Male Urethral Cancer
Male Urethral Malignant Neoplasm
Ureter Squamous Cell Carcinoma
Ureteral Epidermoid Carcinoma
Ovarian Primitive Germ Cell Tumor
Ureter Adenocarcinoma
Adenocarcinoma Of Ureter
Ureteral Adenocarcinoma
Nodular Hidradenoma
Eccrine Nodular Hidradenoma
Eccrine Acrospiroma
Benign Breast Adenomyoepithelioma
Benign Adenomyoepithelioma Of The Breast
Ovarian Germ Cell Teratoma
Germ Cell Teratoma Of Ovary
Ovarian Teratoma
Meibomian Cyst
Chalazion
Meibomian Gland Lipogranuloma
Tarsal Cyst
Mucinous Intrahepatic Cholangiocarcinoma
Mucin-Producing Intrahepatic Cholangiocarcinoma
Lung Clear Cell Carcinoma
Epithelial Predominant Wilms' Tumor
Epithelial Predominant Kidney Adenosarcoma
Epithelial Predominant Renal Wilms Tumor
Epithelial Predominant Renal Wilms Tumour
Epithelial Predominant Wilms' Tumour
Sinonasal Undifferentiated Carcinoma
Highly Aggressive Undifferentiated Carcinoma Of The Nasal Cavity And Paranasal Sinuses
Snuc
Rete Testis Adenoma
Jejunal Cancer
Jejunal Neoplasms
Malignant Neoplasm Of Jejunum
Malignant Tumor Of Jejunum
Fallopian Tube Carcinoma
Fallopian Tube Cancer
Cancer Of The Fallopian Tube
Carcinoma Of Fallopian Tube
Neoplasm Of Fallopian Tube
Fallopian Tube Neoplasms
Fallopian Tube Ca
Fallopian Tube Neoplasm
Malignant Neoplasm Of Uterine Tube
Malignant Tumor Of Fallopian Tube
Malignant Tumour Of Fallopian Tube
Tumor Of The Fallopian Tube
Tumor, Fallopian Tube, Malignant
Malignant Tumor Of Fallopian Tubes
Cancer Of Fallopian Tubes
Malignant Tubal Tumor
Tubal Cancer
Malignant Neoplasm Of Fallopian Tube
Primary Malignant Neoplasm Of Fallopian Tube
Cancer Of The Oviduct
Rectum Squamous Cell Carcinoma
Squamous Cell Carcinoma Of The Rectum
Rectal Squamous Cell Carcinoma
Squamous Carcinoma Of Rectum
Breast Ductal Carcinoma
Ductal Breast Carcinoma
Duct Carcinoma
Carcinoma, Ductal
Mammary Ductal Carcinoma
Ductal Carcinoma
Malignant Syringoma
Microcystic Adnexal Carcinoma
Microcystic Adnexal Carcinoma Of Skin
Syringomatous Carcinoma
Eccrine Epithelioma
Gastric Squamous Cell Carcinoma
Squamous Cell Carcinoma Of Stomach
Squamous Cell Carcinoma Of The Stomach
Epithelioid Type Angiomyolipoma
Epithelioid Angiomyolipoma
Endometrial Squamous Cell Carcinoma
Squamous Cell Carcinoma Of Endometrium
Lung Giant Cell Carcinoma
Carcinoma, Giant Cell
Giant Cell Carcinoma
Giant Cell Lung Carcinoma
Carcinoma Giant Cell
Giant Cell Carcinoma Of Lung
Central Nervous System Fibrosarcoma
Fibrosarcoma Of The Cns
Clear Cell Hidradenoma
Clear Cell Myoepithelioma
Eccrine Acrospiroma
Bladder Clear Cell Adenocarcinoma
Bladder Mesonephric Adenocarcinoma
Clear Cell Adenocarcinoma Of Bladder
Nasal Cavity Adenocarcinoma
Adenocarcinoma Of Nasal Cavity
Adenocarcinoma Of The Nasal Cavity
Periampullary Adenocarcinoma
Anal Paget'S Disease
Anal Paget Disease
Paget'S Disease Of Anus
Paget'S Disease Of The Anus
Paget Disease Of The Anus
Corneal Dystrophy, Posterior Polymorphous, 4
PPCD4
Posterior Polymorphous Corneal Dystrophy 4
Balloon Cell Malignant Melanoma
Keratinizing Squamous Cell Carcinoma
Squamous Cell Carcinoma, Keratinizing
Keratinizing Epidermoid Carcinoma
Cribriform Carcinoma
Ductal Carcinoma, Cribriform Type
Carcinoma Cribriform
Carcinoma, Cribriform
Wolffian Duct Adenoma
Benign Mesonephroma
Mesonephric Adenoma
Mesonephroma, Benign
Fatwo
Female Adnexal Tumor Of Probable Wolffian Origin
Wat
Wolffian Adenoma
Wolffian Adnexal Tumor
Wolffian Tumor
Small Cell Cancer Of The Lung
Small Cell Lung Cancer
Small Cell Lung Carcinoma
Sclc
Small-Cell Cancer Of Lung
Lung Small Cell Carcinoma
Sclc1
Sccl
Cancer, Lung, Small Cell
Small Cell Carcinoma Of Lung
Carcinoma, Small Cell
Duodenum Disease
Duodenal Diseases
Duodenal Disease
Duodenum Disorder
Tonsil Cancer
Tonsillar Neoplasms
Malignant Neoplasm Of Faucial Tonsil
Malignant Neoplasm Of Palatine Tonsil
Malignant Neoplasm Of Tonsil, Faucial
Malignant Tonsillar Tumor
Malignant Tumor Of Tonsil
Tonsillar Carcinoma
Malignant Neoplasm Tonsil
Lung Adenoid Cystic Carcinoma
Adenoid Cystic Carcinoma Of Lung
Pulmonary Adenoid Cystic Carcinoma
Lung Large Cell Carcinoma
Large Cell Carcinoma Of Lung
Large Cell Lung Carcinoma
Large Cell Lung Cancer
Aggressive Digital Papillary Adenocarcinoma
Salivary Gland Disease
Salivary Gland Disorders
Salivary Gland Diseases
Non-Neoplastic Salivary Gland Disease
Non-Neoplastic Salivary Gland Disorder
Disorder Of Salivary Gland
Lesion Of Salivary Gland Nos
Pericardium Cancer
Malignant Neoplasm Of Pericardium
Malignant Tumor Of Pericardium
Pericardial Tumor
Neoplasm Of Pericardium
Hemangioma
Hemangiomas
Eccrine Porocarcinoma
Porocarcinoma
Eccrine Porocarcinoma Of Skin
Malignant Eccrine Poroma
Papilloma
Papillomatosis
Hidradenoma
Adenoma, Sweat Gland
Hidradenoma Of Skin
Sweat Gland Adenoma
Syringoadenoma
Eccrine Acrospiroma
Benign Neoplasm Of Sweat Gland
Paraganglioma
Chemodectoma
Glomus Body Tumor
Paragangliomas
Carotid Body Paraganglioma
Extra-Adrenal Paraganglioma
Bartholin'S Gland Carcinoma
Bartholin Gland Carcinoma
Carcinoma Of Bartholin'S Gland
Bartholin'S Gland Disease
Bartholin Gland Disease
Malignant Acrospiroma
Eccrine Ductal Carcinoma
Hidradenocarcinoma
Anaplastic Syringoma
Eccrine Ductal Carcinoma Of Skin
Clear Cell Eccrine Carcinoma
Malignant Clear Cell Acrospiroma
Malignant Nodular/Clear Cell Hidradenoma
Primary Mucoepidermoid Cutaneous Carcinoma
Sweat Gland Adenocarcinoma
Squamous Cell Carcinoma
Epidermoid Carcinoma
Squamous Cell Cancer
Carcinoma, Squamous Cell
Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor
Squamous Carcinoma
Squamous Cell Epithelioma
Carcinoma Squamous Cell
Neoplasms, Squamous Cell
Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm
Squamous Cell Carcinoma Of Skin
Polycystic Liver Disease 1 With Or Without Kidney Cysts
Polycystic Liver Disease 1
PCLD1
Cyst
Liver Disease, Polycystic, Type 1
Polycystic Liver Disease
Ovarian Germ Cell Cancer
Ovarian Germ Cell Tumor
Malignant Germ Cell Tumor Of Ovary
Germ Cell Neoplasm Of Ovary
Germ Cell Tumor Of Ovary
Mogct
Malignant Ovarian Germ Cell Tumor
Malignant Ovarian Germ Cell Neoplasm
Breast Myoepithelial Neoplasm
Breast Myoepithelial Tumor
Malignant Breast Myoepithelioma
Breast Adenomyoepithelioma
Adenomyoepithelioma Of The Breast
Breast Adenomyoepithelioma With Malignant Change
Malignant Adenomyoepithelioma Of Breast
Renal Pelvis Transitional Cell Carcinoma
Urothelial Cell Carcinoma Of Renal Pelvis
Renal Pelvis Urothelial Carcinoma
Transitional Cell Carcinoma Of Renal Pelvis
Vulvar Sebaceous Carcinoma
Adenomyoma
Lymphangitis
Inflammation Of Lymphatics
Squamous Cell Papilloma
Papilloma
Epidermoid Papilloma
Papilloma, Squamous Cell
Clear Cell Adenocarcinoma
Mesonephroma
Water-Clear Cell Adenocarcinoma
Adenocarcinoma, Clear Cell
Malignant Mesonephroma
Mesonephroid Clear Cell Carcinoma
Mesonephroma, Malignant
Water-Clear Cell Carcinoma
Wolffian Duct Neoplasm
Adenocarcinoma Clear Cell
Mesonephric Tumor
Paranasal Sinus Cancer
Paranasal Sinus Adenoid Cystic Carcinoma
Paranasal Sinus Mucoepidermoid Carcinoma
Paranasal Sinus Squamous Cell Carcinoma
Paranasal Sinus Neoplasms
Adenoid Cystic Carcinoma Of Accessory Sinus
Adenoid Cystic Carcinoma Of Paranasal Sinus
Epidermoid Carcinoma Of The Paranasal Sinus
Mucoepidermoid Carcinoma Of Accessory Sinus
Paranasal Sinus Adenocarcinoma
Squamous Cell Carcinoma Of Paranasal Sinus
Paranasal Sinus Neoplasm
Adenocarcinoma Of Accessory Sinus
Breast Leiomyosarcoma
Leiomyosarcoma Of The Breast
Epididymal Neoplasm
Neoplasm Of Epididymis
Adenofibroma
Malignant Epithelial Mesothelioma
Epithelioid Mesothelioma, Malignant
Breast Mucoepidermoid Carcinoma
Mucoepidermoid Carcinoma Of Breast
Mucoepidermoid Carcinoma Of The Breast
Malignant Biphasic Mesothelioma
Mesothelioma, Biphasic, Malignant
Mixed Mesothelioma
Klatskin'S Tumor
Klatskin Tumor
Hilar Cholangiocarcinoma
Perihilar Cholangiocarcinoma
Hilar Cholangiocellular Carcinoma
Klatskin Tumour
Klatskin'S Tumour
Perihilar Extrahepatic Bile Duct Carcinoma
Hilar Cca
Adenocarcinoma Of Hepatic Duct
Klatskin Tumour Of Biliary Tree
Internal Hemorrhoid
Internal Hemorrhoids
Thymoma
Primary Thymic Epithelial Neoplasm
Primary Thymic Epithelial Tumor
Thymus Neoplasms
Pericardial Mesothelioma
Malignant Mesothelioma Of Pericardium
Malignant Pericardial Mesothelioma
Epithelioid Trophoblastic Tumor
Trophoblastic Tumor, Epithelioid
Peritoneum Cancer
Peritoneal Neoplasm
Cancer Of Peritoneum
Malignant Tumor Of Peritoneum
Peritoneal Neoplasms
Colorectal Cancer
Colon Cancer
Colorectal Carcinoma
Colon Carcinoma
Colorectal Cancer, Susceptibility To
Carcinoma Of Colon
CRC
Colorectal Cancer With Chromosomal Instability, Somatic
Colon Cancer, Somatic
Colon Cancer, Susceptibility To
Colonic Neoplasms
Colorectal Neoplasms
Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic
Colonic Carcinoma
Colorectal Carcinomas
Colon Cancers
Colorectal Cancers
Cancer, Colorectal, Somatic
Cancer, Colon
Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm
Colonic Neoplasm
Malignant Tumor Of Colon
Ovarian Mesodermal Adenosarcoma
Ovarian Mullerian Adenosarcoma
Ovarian Adenosarcoma
Cutaneous Mucoepidermoid Carcinoma
Mucoepidermoid Carcinoma Of Skin
Mucoepidermoid Skin Carcinoma
Skin Carcinoma
Skin Cancer
Carcinoma Of Skin
Ca - Skin Cancer
Cancer Of Skin
Malignant Neoplasm Of Skin
Melanoma And Non-Melanoma Skin Cancer
Skin Cancers
Cancer, Skin
Parachordoma
Erysipeloid
Infection Due To Erysipelothrix Rhusiopathiae
Erysipelothrix Infection
Breast Metaplastic Carcinoma
Metaplastic Carcinoma Of The Breast
Metaplastic Breast Carcinoma
Metaplastic Carcinoma Of Breast
Metaplastic Breast Cancer
Vulvar Disease
Vulvar Diseases
Vulvar Disorders
Syringoma
Syringomas
Eccrine Sweat Gland Neoplasm
Eccrine Skin Neoplasm
Eccrine Tumor
Eccrine Neoplasm
Malignant Eccrine Neoplasm
Biliary Papillomatosis
Bile Duct Papillomatosis
Collecting Duct Carcinoma
Kidney Medullary Carcinoma
Renal Medullary Carcinoma
Bdc
Bellini Carcinoma
Bellini Duct Carcinoma
Cdc
Collecting Duct Carcinoma Of The Kidney
Renal Cell Adenocarcinoma
Carcinoma Of Renal Collecting Duct
Renal Carcinoma, Collecting Duct Type
Renal Cell Carcinoma
Bellini'S Duct Carcinoma
Renal Collecting Duct Carcinoma
Adenocarcinoma Of Kidney
Atrophic Vulva
Atrophy Of Vulva
Papillary Serous Adenocarcinoma
Micropapillary Serous Carcinoma
Serous Surface Papillary Carcinoma
Papillary Serous Carcinoma
Papillary Serous Cystadenocarcinoma
Cervical Clear Cell Adenocarcinoma
Clear Cell Carcinoma Of The Cervix Uteri
Bronchus Cancer
Malignant Neoplasm Of Bronchus And Lung
Bronchus Carcinoma
Bronchogenic Carcinoma
Malignant Neoplasm Of Bronchus Or Lung
Bc - Bronchogenic Carcinoma
Carcinoma, Bronchogenic
Bronchial Neoplasms
Blastoma
Embryoma
Salivary Gland Adenoid Cystic Carcinoma
Cylindroma
Anal Canal Paget'S Disease
Anal Canal Paget Disease
Paget'S Disease Of Anal Canal
Paget'S Disease Of The Anal Canal
Paget Disease Of The Anal Canal
Bile Duct Mucoepidermoid Carcinoma
Mucoepidermoid Carcinoma Of The Bile Duct
Extrahepatic Bile Duct Mucoepidermoid Carcinoma
Esophageal Adenosquamous Carcinoma
Cerebrovascular Benign Neoplasm
Female Urethral Cancer
Female Urethral Malignant Neoplasm
Intraductal Breast Benign Neoplasm
Lung Cancer
Lung Carcinoma
Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To
Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer
Lung Neoplasm
Carcinoma Of Lung
Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer
Nsclc
Lung Neoplasms
Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma
Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic
Lung Cancer, Resistance To
Cancer Of Lung
Cancer Of Bronchus
Cancer Of The Lung
Lung Malignancies
Lung Malignant Tumors
Malignant Lung Tumor
Malignant Tumor Of Lung
Pulmonary Cancer
Pulmonary Carcinoma
Pulmonary Neoplasms
Respiratory Carcinoma
LNCR
Adenocarcinoma Of Lung
Neoplasm Of Lung
Cancer Lung
Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung
Lung Cancers
Lung Carcinomas
Cancer, Lung
Cancer, Lung, Non-Small Cell
Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma
Ascending Colon Cancer
Malignant Tumor Of Ascending Colon
Ca Ascending Colon
Malignant Neoplasm Of Right Colon
Malignant Neoplasm Of Ascending Colon
Struma Ovarii
Intratubular Embryonal Carcinoma
Stage 0 Testicular Embryonal Carcinoma
Choriocarcinoma Of The Testis
Testicular Choriocarcinoma
Villous Adenoma
Adenoma Villous
Adenoma, Villous
Duodenum Adenocarcinoma
Duodenal Adenocarcinoma
Adenosquamous Bile Duct Carcinoma
Bile Duct Adenosquamous Carcinoma
Mature Teratoma
Dermoid Cyst
Benign Teratoma
Intrahepatic Cholangiocarcinoma
Cholangiocarcinoma
Intrahepatic Bile Duct Carcinoma
Peripheral Cholangiocarcinoma
Peripheral Intrahepatic Cholangiocarcinoma
Adenocarcinoma Of Intra-Hepatic Bile Ducts
Cholangiocarcinoma, Unspecified Site
Cholangiocarcinoma Of Liver
Biphasic Synovial Sarcoma
Synovial Sarcoma, Biphasic
Biphasic Sarcoma Of Synovium
Adenocarcinoma In Situ
Breast Lobular Carcinoma
Cancer, Breast, Lobular
Lobular Breast Carcinoma
Bile Duct Cysts
Choledochal Cyst
Choledochal Cysts
Choledochocele
Biliary Cyst
Congenital Choledochal Cyst
Bile Duct Cyst
Congenital Cystic Dilatation Of The Biliary Tract
Congenital Bile Duct Dilatation
Xanthogranulomatous Pyelonephritis
Pyelonephritis, Xanthogranulomatous
Prostatic Urethral Cancer
Bilateral Hypoactive Labyrinth
Hypoactive Bilateral Labyrinthine Dysfunction
Hypoactive Labyrinth, Bilateral
Eccrine Acrospiroma
Acrospiroma
Poroma
Eccrine Hidradenoma
Eccrine Hidradenoma Of Skin
Hidradenoma
Adenoma, Sweat Gland
Benign Neoplasm Of Sweat Gland
Eccrine Poroma
Chromophobe Renal Cell Carcinoma
Chromophobe Adenocarcinoma
Chromophobe Carcinoma Of Kidney
Kidney Chromophobe
Renal Cell Carcinoma, Chromophobe Cell
Crcc
Chrcc
Chromophobe Renal Cell Adenocarcinoma
Chromophobe Renal Carcinoma
Chromophobe Carcinoma
Rectum Neuroendocrine Neoplasm
Neuroendocrine Tumor Of Rectum
Neuroendocrine Tumor Of The Rectum
Net Of The Rectum
Rectal Net
Rectal Neuroendocrine Tumor
Rectal Neuroendocrine Neoplasm
Breast Secretory Carcinoma
Secretory Breast Carcinoma
Juvenile Breast Carcinoma
Juvenile Carcinoma Of The Breast
Juvenile Secretory Carcinoma Of Breast
Juvenile Breast Cancer
Sbc
Secretory Carcinoma Of The Breast
Tinea Cruris
Dermatophytosis Of Groin & Perianal Area
Dermatophytosis Of Groin And Perianal Area
Dhobie Itch
Tinea Of Perianal Region
Jejunal Neoplasm
Jejunal Tumor
Neoplasm Of Jejunum
Tumor Of Jejunum
Ovarian Cystadenoma
Cystoma Serosum Simplex
Simple Cystoma Of Ovary
Simple Cystoma Of The Ovary
Anus Disease
Anal Fissure
Ulcer Of Anus
Anus Diseases
Anal Disease
Anal Fissure And Fistula
Anal Ulcer
Fissure In Ano
Nontraumatic Tear Of Anus
Solitary Anal Ulcer
Abnormality Of The Anus
Anal Disorders
Ulcer Of Anus And Rectum
Solitary Ulcer Of Anus
Stercoral Ulcer Of Anus
Primary Biliary Cholangitis
Primary Biliary Cirrhosis
Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis
Familial Primary Biliary Cirrhosis
Pbc
Hanot Syndrome
Cholestatic Cirrhosis
Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary
Hanot'S Cirrhosis
Biliary Cirrhosis
Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome
Hanot-Rossle Syndrome
Hypertrophic Cirrhosis
Todd Cirrhosis
Hanot Cirrhosis
Charcot Cirrhosis
Mahon-Tannhauser Syndrome
Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis
Monolobular Cirrhosis
Unilobar Cirrhosis
Xanthomatous Biliary Cirrhosis
Middle Ear Adenocarcinoma
Adenocarcinoma Of Middle Ear
Adenocarcinoma Of The Middle Ear
Lung Sarcomatoid Carcinoma
Sarcomatoid Carcinoma Of The Lung
Pulmonary Sarcomatoid Carcinoma
Solid Adenocarcinoma With Mucin Production
Bile Duct Cystadenocarcinoma
Biliary Cystadenocarcinoma
Intrahepatic Bile Duct Cystadenocarcinoma
Intrahepatic Bile Duct Mucinous Cystic Neoplasm With An Associated Invasive Carcinoma
Vaginal Tubulovillous Adenoma
Mediastinal Cancer
Mediastinal Neoplasms
Mediastinal Tumor
Mediastinum Cancer
Neoplasm Of Mediastinum
Tumour Of Mediastinum
Malignant Tumor Of Mediastinum
Intraductal Papilloma
Papilloma, Intraductal
Ductal Papilloma
Papilloma Intraductal
Lung Cancer Susceptibility 3
Lung Adenocarcinoma
Adenocarcinoma Of Lung
LNCR3
Adenocarcinoma Of Lung, Susceptibility To
Bronchogenic Lung Adenocarcinoma
Nonsmall Cell Adenocarcinoma
Adenocarcinoma Lung
Lung Adenocarcinomas
Non-Small Cell Adenocarcinoma
Pancreatic Cancer
Pancreatic Carcinoma
Carcinoma Of Pancreas
Familial Pancreatic Carcinoma
Pancreatic Neoplasm
Pancreatic Carcinoma, Familial
Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma
Pancreatic Tumor
Familial Pancreatic Cancer
Neoplasm Of The Pancreas
Cancer Of The Pancreas
Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic
Ca Body Of Pancreas
Ca Head Of Pancreas
Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm
Exocrine Cancer
Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma
PNCA
Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas
Pancreatic Neoplasms
Pancreatic Tumors
Cancer, Pancreatic
Cancer Of Pancreas
Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Peritoneal Mesothelioma
Malignant Mesothelioma Of Peritoneum
Advanced Malignant Mesothelioma Of Peritoneum
Advanced Malignant Peritoneal Mesothelioma
Advanced Peritoneal Malignant Mesothelioma
Anal Squamous Cell Carcinoma
Epidermoid Anal Carcinoma
Carcinoma Of Anal Margin
Epulis
Epulides
Gingival Polyp
Polyp Of Gum
Papilloma Of Choroid Plexus
Choroid Plexus Papilloma
CPP
Childhood Choroid Plexus Papilloma
Papilloma Choroid Plexus
Papilloma, Choroid Plexus
Choroid Plexus Carcinoma
Main Bronchus Cancer
Malignant Neoplasm Of Main Bronchus
Ca Main Bronchus
Oropharynx Cancer
Oropharyngeal Cancer
Oropharyngeal Carcinoma
Malignant Neoplasm Of Oropharynx
Malignant Oropharyngeal Tumor
Malignant Tumor Of Oropharynx
Malignant Tumour Of Mesopharynx
Oropharyngeal Cancer, Adult
Cancer Of The Oropharynx
Medullary Colon Carcinoma
Mixed Germ Cell Cancer
Mixed Germ Cell Tumor
Mixed Germ Cell Neoplasm
Mixed Germ Cell Tumour
Mixed Teratoma And Seminoma
Small Cell Carcinoma
Small Cell Carcinoma, Intermediate Cell
Intermediate Cell Small Cell Carcinoma
Small Cell Carcinoma - Intermediate Cell
Small Cell Carcinoma Of Lung
Carcinoma, Small Cell
Prostate Neuroendocrine Neoplasm
Neuroendocrine Tumor Of The Prostate
Bladder Transitional Cell Papilloma
Bladder Papilloma
Transitional Cell Papilloma Of Bladder
Urinary Bladder Urothelial Papilloma
Urothelial Papilloma
Bladder Urothelial Papilloma
Endocervical Carcinoma
Carcinoma Of Endocervix
Carcinoma Of The Endocervix
Hepatocellular Carcinoma
Liver Cancer
Primary Liver Cancer
HCC
Hepatoma
Malignant Neoplasm Of Liver
Liver Neoplasms
Cancer, Hepatocellular
Liver Cell Carcinoma
Lcc
Hepatoblastoma, Somatic
Hepatic Cancer
Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract
Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic
Hepatocellular Cancer, Somatic
Ca Liver - Primary
Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm
Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary
Malignant Tumor Of Liver
Neoplasm Of Liver
Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver
Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma
Primary Malignant Liver Neoplasm
Primary Cancer Of Liver
Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt
Hepatocellular Cancer
Neoplasm Of The Liver
Carcinoma, Hepatocellular
Hepatomas
Liver Neoplasm
Liver Carcinoma
Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm
Adult Primary Hepatocellular Carcinoma
Hepatoblastoma
Carcinoma Of Liver
Malignant Liver Tumour
Malignant Hepatic Tumour
Kidney Cortex Disease
Bladder Papillary Transitional Cell Neoplasm
Urinary Bladder Papillary Urothelial Neoplasm
Bladder Papillary Urothelial Neoplasm
Urinary Tract Papillary Transitional Cell Benign Neoplasm
Inverted Papilloma Of Urinary Tract
Papillary Transitional Cell Neoplasm Of The Urinary Tract
Urinary Tract Inverted Papilloma
Inverted Urothelial Papilloma
Ovary Adenocarcinoma
Ovarian Adenocarcinoma
Adenocarcinoma Of The Ovary
Ovarian Adenoacanthoma
Adenocarcinoma Of Ovary
Subareolar Duct Papillomatosis
Adenoma Of The Nipple
Nipple Benign Neoplasm
Tumor Of Nipple
Breast Adenocarcinoma
Mammary Adenocarcinoma
Adenocarcinoma Of Breast
Serous Cystadenocarcinoma
Serous Adenocarcinoma
Cystadenocarcinoma, Serous
Serous Carcinoma
Cystadenocarcinoma Serous
Thyroid Gland Hurthle Cell Carcinoma
Oncocytic Carcinoma Of The Thyroid
Thyroid Cancer, Hurthle Cell
Thyroid Gland Cancer
Thyroid Gland Carcinoma
Malignant Neoplasm Of Thyroid Gland
Malignant Tumour Of Thyroid Gland
Thyroid Neoplasm
Thyroid Neoplasms
Neoplasm Of Thyroid Gland
Thyroid Gland Neoplasm
Head And Neck Cancer, Thyroid
Neoplasm Of The Thyroid Gland
Cancer Of The Thyroid
Primary Malignant Neoplasm Of Thyroglossal Duct
Malignant Neoplasm Of Thyroglossal Duct
Primary Malignant Neoplasm Of Thyroid Gland
Thyroglossal Duct Cancer
Toxic Goitre Malignant Tumour
Cancerous Goitre
Renal Cell Carcinoma, Papillary, 1
Papillary Renal Cell Carcinoma
Hereditary Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma, Sporadic
Papillary Renal Cell Adenocarcinoma
RCCP
RCCP1
Renal Cell Carcinoma, Papillary
Renal Cell Carcinoma, Papillary, 1, Familial And Somatic
Chromophil Carcinoma Of Kidney
Papillary Kidney Carcinoma
Sporadic Papillary Renal Cell Carcinoma
Chromophil Renal Cell Carcinoma
Papillary Renal Carcinoma, Malignant -
Papillary Renal Cell Carcinoma, Bilateral -
Papillary Renal Cell Carcinoma, Familial -
Papillary Renal Cell Carcinoma, Multiple -
Papillary Renal Cell Carcinoma, Sporadic -
Renal Adenocarcinoma
Chromophil Rcc
Hprcc
Renal Cell Carcinoma Papillary
Chromophilic Renal Cell Carcinoma
Prcc
Carcinoma, Renal Cell, Papillary, Type 1
Type 1 Papillary Renal Cell Carcinoma
Renal Cell Carcinoma
Hereditary Papillary Renal Carcinoma
Urinary Bladder Small Cell Neuroendocrine Carcinoma
Small Cell Neuroendocrine Carcinoma Of The Urinary Bladder
Small Cell/Neuroendocrine Carcinoma Of Urinary Bladder
Obstructive Jaundice
Jaundice, Obstructive
Cholestatic Jaundice
Cholestatic Jaundice Syndrome
Obstructive Hyperbilirubinemia
Jaundice Obstructive
Jaundice Cholestatic
Anus Cancer
Anal Cancer
Anal Carcinoma
Malignant Anal Tumor
Cancer Of The Anus
Malignant Neoplasm Of Anus
Anus Neoplasms
Pulmonary Artery Leiomyosarcoma
Leiomyosarcoma Of The Pulmonary Artery
Thoracic Benign Neoplasm
Benign Neoplasm Of Thorax
Rectosigmoid Junction Neoplasm
Neoplasm Of Rectosigmoid Junction
Rectosigmoid Neoplasm
Rectosigmoid Tumor
Rectosigmoid Carcinoma
Carcinoma Of The Rectosigmoid Junction
Malignant Tumor Of Rectosigmoid Junction
Rectosigmoid Junction Cancer
Primary Malignant Neoplasm Of Rectosigmoid Junction
Rectosigmoid Colon Cancer
Carcinoma Of Rectum With Sigmoid
Colorectal Cancer Nos
Colorectal Carcinoma Nos
Rectosigmoid Cancer
Malignant Olfactory Nerve Neoplasm
Malignant Olfactory Nerve Tumor
Malignant Tumor Of Olfactory Nerve
Primary Malignant Neoplasm Of Olfactory Nerve
Respiratory System Benign Neoplasm
Renal Pelvis Carcinoma
Malignant Neoplasm Of Renal Pelvis
Malignant Tumor Of Renal Pelvis
Carcinoma Of Kidney Pelvis
Malignant Renal Pelvis Neoplasm
Renal Pelvis Cancer
Cystic Basal Cell Carcinoma
Skin Cystic Basal Cell Carcinoma
Chronic Pyelonephritis
Microinvasive Cervical Squamous Cell Carcinoma
Early Invasive Cervical Squamous Cell Carcinoma
Colorectal Adenocarcinoma
Adenocarcinoma Of Large Intestine
Skin Benign Neoplasm
Neoplasm Of Skin By Site
Tumor Of The Skin
Skin Tumor
Benign Neoplasm Of Skin
Skin Neoplasms
Mucinous Tubular And Spindle Renal Cell Carcinoma
Mucinous Tubular And Spindle Cell Renal Carcinoma
Cecal Disease
Cecal Diseases
Disorder Of Cecum
Adenosquamous Colon Carcinoma
Adenosquamous Carcinoma Of Colon
Colonic Adenosquamous Carcinoma
Colon Adenosquamous Carcinoma
Ovarian Large-Cell Neuroendocrine Carcinoma
Non-Small-Cell Type Neuroendocrine Carcinoma Of Ovary
Ovarian Large Cell Neuroendocrine Carcinoma
Pulmonary Adenocarcinoma In Situ
Bronchioalveolar Carcinoma
Basosquamous Carcinoma
Carcinoma, Basosquamous
Basisquamous Cell Carcinoma
Basosquamous Cell Carcinoma
Metatypical Carcinoma
Breast Benign Neoplasm
Benign Tumour Of Breast
Benign Neoplasm Of Female Breast
Vulvar Apocrine Adenocarcinoma
Vaginal Carcinosarcoma
Malignant Vaginal Mixed Epithelial And Mesenchymal Tumor
Vaginal Malignant Mixed Mesodermal Tumor
Vaginal Malignant Mixed Mullerian Tumor
Vaginal Mixed Epithelial And Mesenchymal Tumor
Breast Adenoid Cystic Carcinoma
Adenoid Cystic Breast Carcinoma
Adenoid Cystic Carcinoma Of Breast
Mammary Adenocystic Carcinoma
Rectal Disease
Rectal Diseases
Rectal Disorders
Heart Cancer
Malignant Neoplasm Of Heart
Heart Neoplasm
Cardiac Tumor
Malignant Cardiac Tumor
Tumour Of Heart
Heart Neoplasms
Cardiac Carcinoma
Vaginal Cancer
Malignant Neoplasm Of Vagina
Vaginal Neoplasms
Malignant Tumor Of Vagina
Malignant Vaginal Tumor
Neoplasm Of Vagina
Vagina Neoplasm
Vaginal Tumor
Vaginal Carcinoma
Vaginal Malignant Epithelial Tumor
Vaginal Neoplasm
Malignant Vaginal Neoplasm
Vagina Carcinoma
Vaginal Neoplasia
Cancer Of Vagina
Malignant Tumour Of Vagina
Carcinoma Of Vagina
Primary Malignant Neoplasm Of Vagina
Vagina Wall Cancer
Vaginal Wall Cancer
Sublingual Gland Adenoid Cystic Carcinoma
Vascular Cancer
Blood Vessel Tumors
Malignant Vascular Neoplasm
Renal Vein Leiomyosarcoma
Vascular Neoplasms
Blood Vessel Neoplasm
Blood Vessel Tumor
Blood Vessel Tumour Disorder
Haemangiomatous Tumour
Leiomyosarcoma Of The Renal Vein
Malignant Great Vessel Tumor
Malignant Tumor Of Pulmonary Artery
Malignant Tumor Of Pulmonary Vein
Malignant Vascular Tumor
Neoplasm Of Great Vessel
Pulmonary Artery Malignant Neoplasm
Pulmonary Vein Malignant Neoplasm
Vascular Tissue Neoplasm
Vascular Tumors
Blood Vessel Cancer
Neoplasms, Vascular Tissue
Malignant Neoplasm Of Great Vessels
Liver Sarcoma
Hepatic Sarcoma
Sarcoma Of Liver
Lung Carcinoma In Situ
Corneal Dystrophy, Posterior Polymorphous, 1
Posterior Polymorphous Corneal Dystrophy
Ppcd
Maumenee Corneal Dystrophy
Posterior Polymorphous Corneal Dystrophy 1
PPCD1
Corneal Dystrophy, Hereditary Polymorphous Posterior
Corneal Endothelial Dystrophy 1, Autosomal Dominant
Schlichting Dystrophy
Ched1
Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly
Ched1, Formerly
Hereditary Polymorphus Posterior Corneal Dystrophy
Posterior Polymorphous Dystrophy
Hereditary Polymorphous Posterior Corneal Dystrophy
Dystrophy, Corneal, Posterior Polymorphous
Dystrophy, Corneal, Posterior Polymorphous, Type 1
Polymorphous Corneal Dystrophy
Corneal Endothelial Dystrophy 2
Birt-Hogg-Dube Syndrome
Hornstein-Knickenberg Syndrome
Fibrofolliculomas With Trichodiscomas And Acrochordons
BHD
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Multiple Fibrofolliculoma Familial
Bhd Syndrome
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Hydrocele
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Cholangitis, Primary Sclerosing
Primary Sclerosing Cholangitis
PSC
Sclerosing Cholangitis
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Cholangitis Primary Sclerosing
Psc - [Primary Sclerosing Cholangitis]
Benign Peritoneal Mesothelioma
Mesothelioma Of Peritoneum
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Epithelioid Cell Synovial Sarcoma
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Wilms' Tumor
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Colon Cancer
Colon Carcinoma Nos
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Lynch Syndrome
Hereditary Nonpolyposis Colon Cancer
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Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer
Hnpcc
Coca 1
Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer
Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer
Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome
Hereditary Nonpolyposis Colorectal Cancer Syndrome
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Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome
Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis
Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary
Colorectal Cancer, Hereditary Nonpolyposis, Type 1
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别名
Waldenstroem'S Macroglobulinemia
Waldenstroem'S Macroglobulinemia
Waldenstroem'S Macroglobulinemia
Macroglobulinemia Of Waldenstrom
Lymphoplasmacytic Lymphoma With Igm Gammopathy
Lymphoplasmacytic Lymphoma
Waldenstroem'S Macroglobulinemia
Waldenstroem'S Macroglobulinemia
Macroglobulinemia Of Waldenstrom
Lymphoplasmacytic Lymphoma With Igm Gammopathy
Lymphoplasmacytic Lymphoma
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基因 ID
Mus musculus
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MGI:96704
Felis catus
KRT7
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RGD:1310865
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KRT7
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VGNC:74214
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KRT7
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VGNC:30734
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pan Cytokeratin抗体[KRT/1877R]| Abcam中文官网
pan Cytokeratin抗体[KRT/1877R]| Abcam中文官网
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Signal Transduction Cytoskeleton / ECM Cytoskeleton Intermediate Filaments Class I Cytokeratins
Anti-pan Cytokeratin抗体[KRT/1877R] (ab234297)
Datasheet
SDS
Reviews (6)
Submit a question
References (4)
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Key features and details
Rabbit monoclonal [KRT/1877R] to pan Cytokeratin
Suitable for: ICC, IHC-P
Reacts with: Human
Isotype: IgG
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概述
产品名称
Anti-pan Cytokeratin抗体[KRT/1877R]参阅全部 pan Cytokeratin 一抗
描述
兔单克隆抗体[KRT/1877R] to pan Cytokeratin
宿主
Rabbit
经测试应用
适用于:
ICC, IHC-Pmore details
种属反应性
与反应:
Human预测可用于:
Mouse, Rat, Goat, Guinea pig, Cow, Pig, Monkey
免疫原
Tissue, cells or virus corresponding to Human pan Cytokeratin. (Keratin-enriched preparation from cultured human epithelial cells).
阳性对照
IHC-P: Human skin tissue.
ICC: MCF7 cells
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
形式
Liquid
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
存储溶液
pH: 7.2Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA
Concentration information loading...
纯度
Protein A/G purified
纯化说明
Purified from Bioreactor Concentrate by Protein A/G.
克隆
单克隆
克隆编号
KRT/1877R
同种型
IgG
研究领域
Signal Transduction
Cytoskeleton / ECM
Cytoskeleton
Intermediate Filaments
Class I
Cytokeratins
相关产品
Alternative Versions
Anti-pan Cytokeratin antibody [KRT/1877R] - BSA and Azide free (ab236323)
Compatible Secondaries
Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
Isotype control
Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab234297于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用
Ab评论
说明
ICC
Use a concentration of 1 - 2 µg/ml.
IHC-P
(4)
Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Primary incubation for 30 minutes at room temperature.
说明
ICCUse a concentration of 1 - 2 µg/ml.
IHC-PUse a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Primary incubation for 30 minutes at room temperature.
靶标
相关性
Cytokeratins, a group comprising at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratins 1, 4, 5, 6, and 8 are members of the type II neutral to basic subfamily. Monoclonal anti cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. Monoclonal Anti Pan Cytokeratin is a broadly reactive reagent, which recognizes epitopes present in most human epithelial tissues. It facilitates typing of normal, metaplastic and neoplastic cells. Synergy between the various components results in staining amplification. This enables identification of cells, which would otherwise be stained only marginally. The mixture may aid in the discrimination of carcinomas and nonepithelial tumors such as sarcomas, lymphomas and neural tumors. It is also useful in detecting micrometastases in lymph nodes, bone marrow and other tissues and for determining the origin of poorly differentiated tumors.
There are two types of cytokeratins the acidic type I cytokeratins and the basic or neutral type II cytokeratins. Cytokeratins are usually found in pairs comprising a type I cytokeratin and a type II cytokeratin. Usually the type II cytokeratins are 8kD larger than their type I counterparts.
细胞定位
Cytoplasmic
数据库链接
Entrez Gene:
374454 Human
Entrez Gene:
51350 Human
SwissProt:
Q01546 Human
SwissProt:
Q7Z794 Human
别名
pan ck antibody
pan-ck antibody
panck antibody
图片
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-pan Cytokeratin antibody [KRT/1877R] (ab234297)
Formalin-fixed, paraffin-embedded human skin tissue stained for pan Cytokeratin using ab234297 at 1 μg/ml in immunohistochemical analysis.
Immunocytochemistry - Anti-pan Cytokeratin antibody [KRT/1877R] (ab234297)
Immunocytochemistry analysis of MCF7 cells labeling pan Cytokeratin with ab234297 at 2ug/mL followed by Goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red).
实验方案
To our knowledge, customised protocols are not required for this product.
Please try the standard protocols listed below and let us know how you get on.
Click here to view the general protocols
数据表及文件
SDS download
Country/RegionSelect country/region
LanguageSelect language
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ab234297 被引用在 4 文献中.
Moon H et al. Activated TAZ induces liver cancer in collaboration with EGFR/HER2 signaling pathways. BMC Cancer 22:423 (2022).
PubMed: 35439973
Huang N et al. SARS-CoV-2 infection of the oral cavity and saliva. Nat Med 27:892-903 (2021).
PubMed: 33767405
Xu L et al. MEF/KSF-conditioned culture medium: An effective method for in vitro culture of mouse dermal papilla cells with osteogenic differentiation potential. Exp Ther Med 22:828 (2021).
PubMed: 34149874
Huang N et al. Integrated Single-Cell Atlases Reveal an Oral SARS-CoV-2 Infection and Transmission Axis. medRxiv N/A:N/A (2020).
PubMed: 33140061
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IHC - Wholemount abreview for Anti-pan Cytokeratin antibody [KRT/1877R]
Poor
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IHC - Wholemount
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Mouse Tissue (Embryonic Kidney)
Specification
Embryonic Kidney
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Lauren Russell
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提交于 Aug 12 2021
Immunohistochemistry (Frozen sections) abreview for Anti-pan Cytokeratin antibody [KRT/1877R]
Excellent
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Application
Immunohistochemistry (Frozen sections)
Sample
Mouse Tissue sections (Tumor)
Specification
Tumor
Blocking step
(agent) for 30 minute(s) · Concentration: 0.25% · Temperature: 25°C
Fixative
Formaldehyde
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提交于 Jul 05 2021
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-pan Cytokeratin antibody [KRT/1877R]
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Mouse Tissue sections (Endometrium)
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Heat mediated - Buffer/Enzyme Used: Epitope retrieval solution
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No
Specification
Endometrium
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Peroxide block as blocking agent for 5 minute(s) · Concentration: 3% · Temperature: 20°C
Fixative
Formaldehyde
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提交于 Mar 11 2021
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-pan Cytokeratin antibody [KRT/1877R]
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Monkey Tissue sections (Salivary gland)
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Heat mediated - Buffer/Enzyme Used: Tris-EDTA pH 9.0. Citrate pH 6.0
Permeabilization
Yes - 0.2% Triton-PBS
Specification
Salivary gland
Blocking step
Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 22°C
Fixative
Formaldehyde
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提交于 Oct 01 2019
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-pan Cytokeratin antibody [KRT/1877R]
Inconclusive
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample
Mouse Tissue sections (skin)
Antigen retrieval step
Heat mediated - Buffer/Enzyme Used: Tris-EDTA buffer, pH 9.0, citrate pH 6.
Permeabilization
Yes - 0.2% Triton-PBS
Specification
skin
Blocking step
Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 22°C
Fixative
Formaldehyde
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Josune Garcia
Verified customer
提交于 Oct 01 2019
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-pan Cytokeratin antibody [KRT/1877R]
Excellent
Abreviews
Abreviews
Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample
Mouse Tissue sections (Lung)
Antigen retrieval step
Heat mediated
Permeabilization
No
Specification
Lung
Blocking step
Protein Block from ab236469 as blocking agent for 10 minute(s) · Concentration: 100% · Temperature: 22°C
Fixative
Formaldehyde
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The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.
Abcam user community
Verified customer
提交于 Mar 28 2019
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中国医学科学院JBC食管癌最新研究 - 生物通
中国医学科学院JBC食管癌最新研究 - 生物通
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中国医学科学院JBC食管癌最新研究
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时间:2015年04月09日
来源:生物通
编辑推荐:
四月七日,国际著名学术期刊《Journal of Biological Chemistry》发表了中国医学科学院和美国匹茨堡大学的一项最新研究成果。这项研究表征了KLF4-KRT13和食管鳞状细胞癌分化之间的一种关键联系,并为KLF4 受KRT13调控的机制提供了深刻的见解。该研究还阐明了KLF4-KRT13信号通路在SB介导的食管癌细胞分化过程中的重要性。
生物通报道:四月七日,国际著名学术期刊《Journal of Biological Chemistry》发表了中国医学科学院和美国匹茨堡大学的一项最新研究成果,题为“Kruppel like factor 4 promotes esophageal squamous cell carcinoma differentiation by upregulating keratin 13 expression”。 这项研究表征了KLF4-KRT13和食管鳞状细胞癌分化之间的一种关键联系,并为KLF4 受KRT13调控的机制提供了深刻的见解。该研究还阐明了KLF4-KRT13信号通路在SB介导的食管癌细胞分化过程中的重要性。
本文通讯作者是中国医学科学院北京协和医学院肿瘤医院分子肿瘤学国家重点实验室刘芝华研究员,教育部“****奖励计划”特聘教授,国家杰出青年基金获得者。刘芝华研究员1987年毕业于北京大学,1993年在北京大学获博士学位,1993年至1996年在美国华盛顿州立大学从事博士后研究,1997年至今在分子肿瘤学国家重点实验室工作。刘芝华带领的课题组主要致力于食管癌、乳腺癌等常见恶性肿瘤的发病机理研究,涉及的研究领域主要包括肿瘤转移、肿瘤微环境、肿瘤抗药性以及肿瘤标志物和分子靶标等。该科研团队曾经发现孟德尔隐性主基因对食管癌发生起决定性作用,并阐释了遗传因素在食管癌变过程中的重要作用,科研成果曾经发表在Clin Cancer Res、Cancer Res、JBC等知名期刊。
食管癌是一种侵袭性的疾病,倾向于局部病灶和远端蔓延,是导致全球癌症相关死亡的第六大原因。根据不同的组织学、遗传学和表遗传学改变和癌起源地,将食管癌分为几种亚型,可致使手术切除、放疗和化疗后有不同的预后结果。食管癌最常分布在东亚国家。虽然在局部控制率和长期生存率方面,手术是食管癌的最佳治疗,但在大多数接受完整肿瘤切除术的病例中,会发生复发和肝转移,从而导致只有25%的5年生存率。目前缺乏有效的靶向治疗,对标准化疗的反应也较差,往往归因于这种疾病迅速致命的预后。因此,我们需要理解驱动ESCC的分子机制,并将这方面的知识转化为新的、令人鼓舞的干预策略和治疗选择。延伸阅读:中国医学科学院食管癌基因组研究取得重大突破。
鳞状细胞分化需要特定于分化过程的基因的协同活化和抑制,这一程序的中断伴有恶性上皮细胞转化。探索控制表皮细胞增殖和终末分化的基因,对于我们更好地了解食管癌变至关重要。
KLF4是KLF转录因子家族成员,参与细胞的增殖和分化。KRT是一个中间丝状体蛋白家族,以一种细胞类型特异性和分化依赖性的方式在上皮细胞中表达。越来越多的证据表明,个体KRTs在各种各样肿瘤中的差异表达,使得它们成为组织病理学癌亚型的有用标记,并提供了关于肿瘤分化状态和起源的相关信息,尤其是转移性肿瘤。
这项研究使用免疫组化法,对食管鳞状细胞癌(ESCC)临床标本中的KLF4进行了分析,发现KLF4减少与肿瘤低分化明显相关。此外,该研究确定,当丁酸钠(SB)诱导食管癌分化和G1期阻滞时,KLF4和KRT13的水平无疑是增强的。相反,抑制KLF4和KRT13可解除SB诱导的G1-S转换抑制。分子研究表明,KLF4可转录调节KRT13,并且在食管鳞癌组织和细胞系中,这两个分子的表达是明显相关的。
总的来说,这些结果表征了KLF4-KRT13和ESCC分化之间的一种关键联系,并为KLF4 受KRT13调控的机制提供了深刻的见解。该研究还阐明了KLF4-KRT13信号通路在SB介导的食管癌细胞分化过程中的重要性。因此,这项研究,为通过具体评价KLF4 和 KRT13表达变化识别ESCC恶性进展的新生物标志物,打开了一条独特的途径。
(生物通:王英)
生物通推荐原文摘要:Kruppel like factor 4 promotes esophageal squamous cell carcinoma differentiation by upregulating keratin 13 expressionAbstract:Squamous cell differentiation requires the coordinated activation and repression of genes specific to the differentiation process, disruption of this program accompanies malignant transformation of epithelium. The exploration of genes which control epidermal proliferation and terminal differentiation is vital to better understand esophageal carcinogenesis. KLF4 is a member of the KLF family of transcription factors and involved in both cellular proliferation and differentiation. The present study using immunohistochemistry analysis of KLF4 in clinical specimens of esophageal squamous cell carcinoma (ESCC) exhibited that decreased KLF4 was substantially associated with poor differentiation. Moreover, we determined that both KLF4 and KRT13 level were undoubtedly augmented upon sodium butyrate (SB) induced ESCC differentiation and G1-phase arrest. Conversely, silencing of KLF4 and KRT13 abrogated the inhibition of G1-S transition induced by SB. Molecular investigation demonstrated that KLF4 transcriptionally regulated KRT13 and the expression of the two molecules appreciably correlated in ESCC tissues and cell lines. Collectively, these results suggest that KLF4 transcriptionally regulates KRT13 and involves in ESCC cell differentiation.
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